McGuffin P, Asherson P, Owen M, Farmer A
Department of Psychological Medicine, University of Wales College of Medicine, Cardiff.
Br J Psychiatry. 1994 May;164(5):593-9. doi: 10.1192/bjp.164.5.593.
The evidence for a genetic contribution to schizophrenia is compelling. However, the pattern of inheritance is complex and it is usually assumed that environmental factors also have a role that will eventually be identified. We argue that this is not necessarily the case. While a hypothesis combining genetic diathesis with environmental stress cannot be disproved, it is also possible that 'non-genetic' factors consist entirely of stochastic events affecting gene expression or structure.
遗传因素对精神分裂症有影响这一证据是令人信服的。然而，遗传模式很复杂，通常认为环境因素也起作用，且最终会被识别出来。我们认为未必如此。虽然基因易感性与环境压力相结合的假说无法被推翻，但“非遗传”因素也有可能完全由影响基因表达或结构的随机事件组成。
