Gudumak V S, Popovich P I, Nigulianu V I, Marchenko V P, Dontsu O N, Tsaran O A
Klin Lab Diagn. 1994(3):17-9.
Amino acid metabolism was studied experimentally during prolonged administration of a mixture of organochlorine, -metallic, and -phosphorus pesticides and in subjects occupationally exposed to pesticides for a long time. A marked increase of blood serum and liver levels of ser, glu, gly, ala, val, isolei, tyr, phen and a decrease of cystine were detected in white rats. Blood serum serine and threonine hydratases activities increased in parallel with increase of pesticide mixture dose. Reduced levels of taurine, cystine, methionine, alanine and increased levels of phenylalanine were revealed in subjects after prolonged exposure to pesticides. Analysis of blood serum amino acid metabolism parameters may be used as diagnostic criteria of metabolic disorders in a body exposed to pesticides.
在长期施用有机氯、金属和磷农药混合物期间以及在长期职业性接触农药的受试者中，对氨基酸代谢进行了实验研究。在白鼠中检测到血清和肝脏中丝氨酸、谷氨酸、甘氨酸、丙氨酸、缬氨酸、异亮氨酸、酪氨酸、苯丙氨酸水平显著升高，胱氨酸水平降低。血清丝氨酸和苏氨酸水化酶活性随着农药混合物剂量的增加而平行升高。长期接触农药的受试者中，牛磺酸、胱氨酸、蛋氨酸、丙氨酸水平降低，苯丙氨酸水平升高。血清氨基酸代谢参数分析可作为接触农药人体代谢紊乱的诊断标准。
