Rokanol B2和Rokamid R1的遗传毒性评估。
Genotoxicity assessment of Rokanol B2 and Rokamid R1.
作者信息
Janik-Spiechowicz E, Barański B, Dziubałtowska E, Wyszyńska K, Przybojewska B, Chwiałkowska-Liro W, Przondo J
机构信息
Department of Carcinogenesis, Teratogenesis and Mutagenesis, Nofer Institute of Occupational Medicine, Lodz, Poland.
出版信息
Int J Occup Med Environ Health. 1994;7(1):51-7.
Two surface-active compounds, Rokanol B2 and Rokamid R1, were examined with three types of screening tests: 1. standard Ames test in vitro using S. typhimurium TA97a, TA98, TA100 and TA102 strains; 2. micronucleus test in vivo; 3. sister chromatid exchange (SCE) on bone marrow cells of Balb C mice. Negative results of the testing, in terms of the effects of activity of both the technical preparations on S. typhimurium cells and bone marrow of Balb C mice, were found for both tested chemicals.
对两种表面活性化合物Rokanol B2和Rokamid R1进行了三种类型的筛选试验：1. 使用鼠伤寒沙门氏菌TA97a、TA98、TA100和TA102菌株进行的标准体外艾姆斯试验；2. 体内微核试验；3. 对Balb C小鼠骨髓细胞进行的姐妹染色单体交换（SCE）试验。就两种受试化学品对鼠伤寒沙门氏菌细胞和Balb C小鼠骨髓的活性影响而言，两种受试化学品的测试结果均为阴性。
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