Lu L
Walther Oncology Center, Indiana University, Indianapolis 46202.
J Hematother. 1993 Summer;2(2):201-2. doi: 10.1089/scd.1.1993.2.201.
A population of very primitive cells has been purified from umbilical-cord blood. These primitive cells appear to be the equivalent of murine, high-proliferative potential, colony-forming cells (HPP-CFC). This analogy is based on the size of the colonies (1 to > 2.5 mm in diameter) and the replating potential of up to the fifth generation of individual colonies. At a single-cell level and in the presence of serum, increasing numbers of cytokines resulted in increasing numbers of HPP-CFC colonies. No HPP-CFC colonies were detected in the absence of serum, suggesting that additional cytokines are required for formation of these high-proliferative potential colonies.
已从脐带血中纯化出一群非常原始的细胞。这些原始细胞似乎等同于小鼠的高增殖潜能集落形成细胞（HPP-CFC）。这种类比基于集落的大小（直径为1至>2.5毫米）以及单个集落传代至第五代的再增殖潜能。在单细胞水平且存在血清的情况下，细胞因子数量增加导致HPP-CFC集落数量增加。在无血清条件下未检测到HPP-CFC集落，这表明形成这些高增殖潜能集落还需要其他细胞因子。
