Farrera J A, Jaumà A, Ribó J M, Peiré M A, Parellada P P, Roques-Choua S, Bienvenue E, Seta P
Departament de Química Orgànica, Universitat de Barcelona, Catalonia, Spain.
Bioorg Med Chem. 1994 Mar;2(3):181-5. doi: 10.1016/s0968-0896(00)82013-1.
Bilirubin, biliverdin and their serum albumin complexes were tested as oxyradical scavengers (superoxide generated by the xanthine/xanthine oxidase system and peroxyl radical-trapping antioxidant ability). As superoxide scavengers the free bile pigments showed activities near to that of serum albumin, higher than the water soluble vitamin E analog Trolox and lower than ascorbic acid. The peroxyl radical-trapping antioxidant abilities of the tested bile pigments were much higher than those of the serum albumin and of the same order as their serum albumin complexes. This interaction with peroxyl radicals showed different stoichiometric factors for bilirubin (approximately 2) and biliverdin (approximately 4).
对胆红素、胆绿素及其血清白蛋白复合物作为氧自由基清除剂进行了测试（通过黄嘌呤/黄嘌呤氧化酶系统产生超氧化物以及过氧自由基捕获抗氧化能力）。作为超氧化物清除剂，游离胆汁色素的活性接近血清白蛋白，高于水溶性维生素E类似物Trolox且低于抗坏血酸。所测试的胆汁色素的过氧自由基捕获抗氧化能力远高于血清白蛋白，且与其血清白蛋白复合物处于同一水平。这种与过氧自由基的相互作用显示，胆红素（约为2）和胆绿素（约为4）具有不同的化学计量系数。
