Calvet J P
Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City 66160-7421.
Curr Opin Nephrol Hypertens. 1994 May;3(3):340-8. doi: 10.1097/00041552-199405000-00017.
The large diversity of genetic and nongenetic causes of polycystic kidney disease begs the question of whether there is a common denominator in the process of cyst formation. Accumulating evidence now indicates that cysts are made up of immature epithelium, which suggest that cystic transformation may be caused by an arrested developmental process that locks cells in a unique differentiated state. Although there may be any number of possible causes of this cystic change, it is proposed that one unifying mechanism may be subcritical injury-induced cellular dedifferentiation.
多囊肾病的遗传和非遗传病因多种多样，这就引出了一个问题：在囊肿形成过程中是否存在一个共同因素。现在越来越多的证据表明，囊肿由未成熟的上皮细胞组成，这表明囊性转化可能是由发育过程停滞导致细胞锁定在一种独特的分化状态引起的。尽管这种囊性变化可能有多种潜在原因，但有人提出，一个统一的机制可能是亚临界损伤诱导的细胞去分化。
