Diamond M S, Springer T A
Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115.
Curr Biol. 1994 Jun 1;4(6):506-17. doi: 10.1016/s0960-9822(00)00111-1.
The integrins are a family of transmembrane heterodimeric adhesion molecules that play important roles in wound healing, immune system function and organ development. Recent studies indicate that adhesion of integrins to their ligands is not constitutive but is dynamically regulated by intracellular signal transduction pathways.
整合素是一类跨膜异二聚体黏附分子家族，在伤口愈合、免疫系统功能及器官发育中发挥重要作用。近期研究表明，整合素与其配体的黏附并非组成性的，而是受细胞内信号转导通路动态调控。
