Schwartz M A, Schaller M D, Ginsberg M H
Department of Vascular Biology, Scripps Research Institute, La Jolla, California 92037, USA.
Annu Rev Cell Dev Biol. 1995;11:549-99. doi: 10.1146/annurev.cb.11.110195.003001.
Integrins receive signals from other receptors that lead to activation of ligand binding (inside-out signaling) and matrix assembly. Upon binding ligands, they also activate intracellular signaling pathways. These signals converse with pathways that are initiated by soluble ligands to regulate cell functions. In this way, cell adhesion is coordinated with other events to orchestrate complex cellular behavior.
整合素从其他受体接收信号，这些信号导致配体结合的激活（由内向外信号传导）和基质组装。在结合配体后，它们还会激活细胞内信号通路。这些信号与由可溶性配体启动的信号通路相互作用，以调节细胞功能。通过这种方式，细胞黏附与其他事件相协调，以编排复杂的细胞行为。
