Ljunghusen O, Lundahl J, Nettelblad H, Nilsson B, Sjögren F, Stendahl O
Department of Clinical Immunology, Karolinska Hospital, Stockholm, Sweden.
Inflammation. 1996 Jun;20(3):229-41. doi: 10.1007/BF01488201.
In this study we followed the development of an inflammatory response in a group of patients the first week after a burn injury. We detected elevated plasma endotoxin levels, on at least one occasion, in 6 of 8 patients. No endotoxin was detected in the two patients with the lowest total burned surface area (< or = 30%). We found evidence of complement activation as increased C3a levels, in parallel with a production of inflammatory cytokines (TNF-alpha, IL-6). The TNF-alpha levels increased significantly during the observation period, while the IL-6 levels were elevated already at admission, and remained so. Elevated levels of soluble E-selectin were detected, indicating endothelial cell activation. Despite the inflammatory response and a loss of inflammatory cells during the first days of the monitoring period, we found no evidence of cellular activation measured as increased expression of beta 2 integrin CD11b, nor increased plasma levels of soluble L-selectin.
在本研究中，我们追踪了一组烧伤患者伤后第一周炎症反应的发展情况。在8名患者中，至少有一次检测到6名患者血浆内毒素水平升高。在烧伤总面积最低（≤30%）的两名患者中未检测到内毒素。我们发现了补体激活的证据，表现为C3a水平升高，同时伴有炎症细胞因子（TNF-α、IL-6）的产生。在观察期内，TNF-α水平显著升高，而IL-6水平在入院时就已升高，并持续保持升高。检测到可溶性E-选择素水平升高，表明内皮细胞被激活。尽管在监测期的头几天有炎症反应且炎症细胞有所减少，但我们未发现以β2整合素CD11b表达增加衡量的细胞激活证据，也未发现可溶性L-选择素血浆水平升高。
