Yamazaki S, Maruyama M, Cagampang F R, Inouye S T
Laboratory of Integrative Brain Function, Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan.
Brain Res. 1994 Jul 18;651(1-2):329-31. doi: 10.1016/0006-8993(94)90713-7.
Signal transduction by second messengers has long been hypothesized to be involved in the circadian system in the suprachiasmatic nucleus (SCN) of the mammalian brain. The present study reports that the concentration of adenosine-3',5'-monophosphate (cyclic AMP or cAMP) in the SCN region exhibited a circadian fluctuation with two peaks during a day under constant conditions. While a sharp peak at around the end of the subjective night was observed only in the SCN region, the other peak in the late subjective day was also found in the anterior hypothalamic area. The distinct cAMP peak at the late subjective night contrasts with the daytime peaks in electrical and metabolic activity rhythms of the SCN.
长期以来，人们一直推测第二信使介导的信号转导参与了哺乳动物大脑视交叉上核（SCN）中的昼夜节律系统。本研究报告称，在恒定条件下，SCN区域中3',5'-环磷酸腺苷（环磷酸腺苷或cAMP）的浓度在一天内呈现出昼夜波动，有两个峰值。虽然仅在SCN区域观察到在主观夜间结束时左右出现一个尖峰，但在主观白天后期的另一个峰值也在前下丘脑区域发现。主观夜间后期明显的cAMP峰值与SCN电活动和代谢活动节律的白天峰值形成对比。
