Yu G L, Jin Y H, Sun Y P
Testing Department, Shenyang Seventh People's Hospital.
Zhonghua Yi Xue Za Zhi. 1994 Mar;74(3):153-4, 191.
Ten families living in Shenyang city with multiple cases of essential hypertension were studied by HLA haplotype analysis. They were selected strictly in accordance with the methods of sibling pair analysis and lods analysis. The obtained ratio of HLA haplotype sharing among affected siblings were 28.6%(2): 52.4%(1): 19.0%(0), P > 0.9. It is indicated that the haplotype shared randomly among affected siblings. The results of Lods analysis were Q = 0.40, Lods = 0.046, Pr = 1.112. These results showed that there is no evidence of patients with essential hypertension susceptible to gene linked with HLA.
通过HLA单倍型分析对沈阳市10个有多名原发性高血压患者的家庭进行了研究。他们是严格按照同胞对分析和对数优势计分分析方法选取的。在患病同胞中获得的HLA单倍型共享率为28.6%（2条）：52.4%（1条）：19.0%（0条），P>0.9。这表明在患病同胞中，单倍型是随机共享的。对数优势计分分析结果为Q = 0.40，对数优势计分=0.046，Pr = 1.112。这些结果表明，没有证据表明原发性高血压患者易患与HLA相关的基因。
