Chen P Q, Li G Q, Guo X B
Sanya Tropical Medicine Institute, Guangzhou College of Traditional Chinese Medical.
Zhonghua Yi Xue Za Zhi. 1994 Apr;74(4):209-10, 253-4.
27 patients with gametocytes of P. falciparum were divided into groups A, B and C. 1,200 mg of artemisinine was given as a daily dose for 5 days to group A, 750 mg of mefloquine plus 45 mg of primaquine as a single dose to group C. After medication, gametocyte count was observed daily in addition to the infectivity of gametocytes of P. falciparum to Anopheles dirus. In group A, the density of gametocytes and the infectivity were significantly reduced on days 4, 7, 14 and 21 during the study. In group B, the density of gametocytes was significantly reduced on days 7, 14 and 21 and the infectivity was obviously lowered on days 14 and 21 after medication. In group C, gametocytes disappeared in 5 out of 9 patients with the failure of infection to mosquitoes on day 4 after treatment. This indicates that artemisinine can effectively influence the infectivity of gametocytes of P. falciparum. Artemisinine is superior to mefloquine in blocking the transmission of P. falciparum malaria.
27例恶性疟配子体患者被分为A、B、C三组。A组给予青蒿素每日剂量1200毫克，连用5天；C组给予甲氟喹750毫克加伯氨喹45毫克单剂量。用药后，除观察恶性疟配子体对大劣按蚊的感染性外，每日观察配子体计数。在A组，研究期间第4、7、14和21天配子体密度和感染性显著降低。在B组，用药后第7、14和21天配子体密度显著降低，第14和21天感染性明显降低。在C组，9例患者中有5例在治疗后第4天配子体消失，对蚊子的感染失败。这表明青蒿素可有效影响恶性疟配子体的感染性。青蒿素在阻断恶性疟传播方面优于甲氟喹。
