Chen P Q, Li G Q, Guo X B, He K R, Fu Y X, Fu L C, Song Y Z
Sanya Tropical Medicine Institute, Guangzhou College of Traditional Chinese Medicine.
Chin Med J (Engl). 1994 Sep;107(9):709-11.
Twenty-seven patients with gametocytes of Plasmodium falciparum (PF) were divided into groups A, B, and C. A daily dose of 1200 mg artemisinin was given for 5 days to group A, a state dose of 750 mg of mefloquine to group B and a single dose of 750 mg mefloquine combined with 45 mg primaquine to group C. After treatment, the gametocyte count was taken daily, and infectivity of the gametocytes to Anopheles dirus via membrane feeding was also studied. Results showed that in group A, the density of gametocyte and infectivity were significantly reduced on days 4, 7, 14 and 21 after treatment; In group B, the gametocytes were significantly reduced on days 7, 14 and 21 and infectivity was significantly cut down on days 14 and 21 after medication. In group C, gametocytes disappeared in 5 out of 9 patients with failure of infecting mosquitoes in all 9 patients on day 4 after treatment. These indicate that artemisinin can effectively influence the infectivity of gametocytes of PF. Artemisinin is much better in blocking the transmission of PF malaria than mefloquine.
27例恶性疟原虫（PF）配子体患者被分为A、B、C三组。A组给予每日1200毫克青蒿素，持续5天；B组给予750毫克甲氟喹的标准剂量；C组给予750毫克甲氟喹单剂量联合45毫克伯氨喹。治疗后，每日进行配子体计数，并研究配子体通过膜饲对大劣按蚊的感染性。结果显示，A组在治疗后第4、7、14和21天，配子体密度和感染性显著降低；B组在用药后第7、14和21天配子体显著减少，在第14和21天感染性显著降低。C组9例患者中有5例在治疗后第4天配子体消失，所有9例患者均未感染蚊子。这些表明青蒿素可有效影响PF配子体的感染性。青蒿素在阻断PF疟疾传播方面比甲氟喹要好得多。
