Pruchon E, Chauveinc L, Sabatier L, Dutrillaux A M, Ricoul M, Delattre J Y, Vega F, Poisson M, Hor F, Dutrillaux B
Laboratoire de Cytogénétique et Génétique, Fontenay-aux-Roses, France.
Cancer Genet Cytogenet. 1994 Sep;76(2):85-92. doi: 10.1016/0165-4608(94)90454-5.
A cytogenetic analysis was performed on 19 recurrent gliomas all of which had been treated by radiotherapy. All cases exhibited clonal chromosomal anomalies, the tumors were classified into four categories in relation to their mono- or polyclonality and to the presence or absence of a clonal evolution. Polyclonal tumors without clonal evolution had a delay of recurrence significantly longer than monoclonal or polyclonal tumors with clonal evolution. This difference could be related to the presence of clones with different malignant potential, which could be differentiated by their pattern of chromosomal aberrations. The malignant potential of "highly malignant" clones resulted from the juxtaposition of imbalances, such as monosomy 10, as in high-grade primary gliomas, and presumably radiation-induced structural rearrangements. That of clones of low malignancy was almost limited to the presence of multiple balanced structural rearrangements, probably induced by radiation.
对19例复发性胶质瘤进行了细胞遗传学分析，所有病例均接受过放射治疗。所有病例均表现出克隆性染色体异常，根据其单克隆或多克隆性以及是否存在克隆进化，将肿瘤分为四类。无克隆进化的多克隆肿瘤复发延迟明显长于有克隆进化的单克隆或多克隆肿瘤。这种差异可能与具有不同恶性潜能的克隆的存在有关，这些克隆可通过其染色体畸变模式加以区分。“高度恶性”克隆的恶性潜能源于不平衡的并列，如10号染色体单体，类似于高级别原发性胶质瘤，可能还有辐射诱导的结构重排。低恶性克隆的恶性潜能几乎仅限于存在多个可能由辐射诱导的平衡结构重排。
