Li Y S, Ramsay D A, Macdonald D R, Del Maestro R F
Department of Pathology, Victoria Hospital, London, Ontario, Canada.
J Neurooncol. 1997 Mar;32(1):7-17. doi: 10.1023/a:1005794815663.
The karyotypes of 18 primary 'untreated' gliomas, 6 recurrent gliomas treated with radiotherapy and/or chemotherapy and 2 gliomas before and after treatment are described, based on observations using standard cytogenetic techniques. In comparison to the untreated gliomas there were relatively consistent chromosome differences in the treated gliomas, including (1) deletions of the long arm of chromosome 7 with breakpoint at q22, possibly induced by alkylating agents, and (2) numerous single cell abnormalities or unrelated clones of structural abnormalities, presumably induced by radiotherapy.
基于使用标准细胞遗传学技术的观察结果，描述了18例原发性“未经治疗”的神经胶质瘤、6例接受放疗和/或化疗的复发性神经胶质瘤以及2例治疗前后的神经胶质瘤的核型。与未经治疗的神经胶质瘤相比，接受治疗的神经胶质瘤存在相对一致的染色体差异，包括：（1）7号染色体长臂在q22处断裂缺失，可能由烷化剂诱导；（2）许多单细胞异常或结构异常的不相关克隆，可能由放疗诱导。
