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Monoclonal antibodies as agonists: an expanded role for their use in cancer therapy.

作者信息

Vitetta E S, Uhr J W

机构信息

Cancer Immunobiology Center, University of Texas Southwestern Medical Center at Dallas 75235-8576.

出版信息

Cancer Res. 1994 Oct 15;54(20):5301-9.

PMID:7923157
Abstract
摘要

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Monoclonal antibodies as agonists: an expanded role for their use in cancer therapy.作为激动剂的单克隆抗体：其在癌症治疗中的应用范围扩大
Cancer Res. 1994 Oct 15;54(20):5301-9.
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Anti-CD45 and anti-CD52 (Campath) monoclonal antibodies effectively eliminate systematically disseminated human non-Hodgkin's lymphoma B cells in Scid mice.抗CD45和抗CD52（Campath）单克隆抗体可有效清除Scid小鼠体内系统性播散的人类非霍奇金淋巴瘤B细胞。
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A human tumor xenograft model of therapy with a bispecific monoclonal antibody targeting c-erbB-2 and CD16.一种使用靶向c-erbB-2和CD16的双特异性单克隆抗体进行治疗的人肿瘤异种移植模型。
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Production of anti-tumor human monoclonal antibodies using different approaches.使用不同方法生产抗肿瘤人单克隆抗体。
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Cancer dormancy: lessons from a B cell lymphoma and adenocarcinoma of the prostate.癌症休眠：来自B细胞淋巴瘤和前列腺腺癌的启示。
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Comparative activity of Sant7 and anti-IL-6, IL-6R monoclonal antibodies in a murine model of B-cell lymphoma.Sant7与抗IL-6、IL-6R单克隆抗体在B细胞淋巴瘤小鼠模型中的活性比较
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CpG-A and B oligodeoxynucleotides enhance the efficacy of antibody therapy by activating different effector cell populations.CpG-A和B寡脱氧核苷酸通过激活不同效应细胞群体增强抗体治疗的疗效。
Cancer Res. 2003 Sep 1;63(17):5595-600.
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Establishment of new SCID and nude mouse models of human B leukemia/lymphoma and effective therapy of the tumors with immunotoxin and monoclonal antibody: marked difference between the SCID and nude mouse models in the antitumor efficacy of monoclonal antibody.人B淋巴细胞白血病/淋巴瘤新的严重联合免疫缺陷（SCID）和裸鼠模型的建立以及用免疫毒素和单克隆抗体对肿瘤进行有效治疗：SCID和裸鼠模型在单克隆抗体抗肿瘤疗效方面的显著差异
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Tumour dormancy and cell signalling--III: Role of hypercrosslinking of IgM and CD40 on the induction of cell cycle arrest and apoptosis in B lymphoma cells.肿瘤休眠与细胞信号传导——III：IgM和CD40的过度交联在诱导B淋巴瘤细胞周期停滞和凋亡中的作用
Ther Immunol. 1995 Jun;2(3):125-36.

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Targeted cytotoxic effect of anti-JL1 immunotoxin against a human leukemic cell line and its clinical implications.抗JL1免疫毒素对人白血病细胞系的靶向细胞毒性作用及其临床意义。
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Human tumor growth suppression by apoptosis induced with anti-ErbB-2 chimeric monoclonal antibody.抗ErbB-2嵌合单克隆抗体诱导凋亡对人类肿瘤生长的抑制作用。
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Homodimerization of tumor-reactive monoclonal antibodies markedly increases their ability to induce growth arrest or apoptosis of tumor cells.肿瘤反应性单克隆抗体的同型二聚化显著增强了它们诱导肿瘤细胞生长停滞或凋亡的能力。
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10
Tumor dormancy and cell signaling: anti-mu-induced apoptosis in human B-lymphoma cells is not caused by an APO-1-APO-1 ligand interaction.肿瘤休眠与细胞信号传导：抗μ诱导人B淋巴瘤细胞凋亡并非由APO-1-APO-1配体相互作用所致。
Proc Natl Acad Sci U S A. 1996 Mar 5;93(5):2165-8. doi: 10.1073/pnas.93.5.2165.