抗ErbB-2嵌合单克隆抗体诱导凋亡对人类肿瘤生长的抑制作用。

Human tumor growth suppression by apoptosis induced with anti-ErbB-2 chimeric monoclonal antibody.

作者信息

Sasaki S, Tsujisaki M, Jinnohara T, Ishida T, Sekiya M, Adachi M, Takahashi S, Hinoda Y, Imai K

机构信息

First Department of Internal Medicine, Sapporo Medical University.

出版信息

Jpn J Cancer Res. 1998 May;89(5):562-70. doi: 10.1111/j.1349-7006.1998.tb03298.x.

DOI:10.1111/j.1349-7006.1998.tb03298.x

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5921853/

Abstract

We established an anti-ErbB-2 mouse-human chimeric monoclonal antibody (MoAb), CH401, which was able to kill cancer cells overexpressing the ErbB-2 protein in vitro. The analysis of the killing mechanism indicated that MoAb CH401 might be the first anti-erbB-2 mouse-human chimeric MoAb which can induce the apoptosis of cancer cells, since morphological changes and DNA fragmentation were recognized in MoAb CH401-treated cells. The ErbB-2 receptor appears to have two opposing functions: acting as a receptor both for a growth factor and for an apoptotic factor. Our results indicate that MoAb CH401 treatment may prove to be very useful for cancer therapy.

摘要

我们制备了一种抗ErbB-2小鼠-人嵌合单克隆抗体（MoAb）CH401，它能够在体外杀死过表达ErbB-2蛋白的癌细胞。对杀伤机制的分析表明，MoAb CH401可能是首个能够诱导癌细胞凋亡的抗ErbB-2小鼠-人嵌合单克隆抗体，因为在经MoAb CH401处理的细胞中观察到了形态学变化和DNA片段化。ErbB-2受体似乎具有两种相反的功能：作为生长因子和凋亡因子的受体。我们的结果表明，MoAb CH401治疗可能对癌症治疗非常有用。

相似文献

1

Human tumor growth suppression by apoptosis induced with anti-ErbB-2 chimeric monoclonal antibody.抗ErbB-2嵌合单克隆抗体诱导凋亡对人类肿瘤生长的抑制作用。

Jpn J Cancer Res. 1998 May;89(5):562-70. doi: 10.1111/j.1349-7006.1998.tb03298.x.

2

[Monoclonal antibody induces apoptosis against cancer cells].

Nihon Rinsho. 2002 Mar;60(3):451-6.

3

Establishment and characterization of mouse-human chimeric monoclonal antibody to erbB-2 product.抗erbB-2产物的小鼠-人嵌合单克隆抗体的建立与鉴定

Jpn J Cancer Res. 1994 Feb;85(2):172-8. doi: 10.1111/j.1349-7006.1994.tb02079.x.

4

[Antibody treatment for cancer].

Nihon Geka Gakkai Zasshi. 2000 Sep;101(9):607-11.

5

Monoclonal antibody to HER-2/neureceptor modulates repair of radiation-induced DNA damage and enhances radiosensitivity of human breast cancer cells overexpressing this oncogene.抗HER-2/神经受体单克隆抗体可调节辐射诱导的DNA损伤修复，并增强过表达该癌基因的人乳腺癌细胞的放射敏感性。

Cancer Res. 1999 Mar 15;59(6):1347-55.

6

Potent inhibition of human gastric cancer by HER2-directed induction of apoptosis with anti-HER2 antibody and caspase-3 fusion protein.抗 HER2 抗体和 caspase-3 融合蛋白诱导凋亡对人胃癌的强效抑制作用。

Gut. 2010 Mar;59(3):292-9. doi: 10.1136/gut.2008.155226. Epub 2009 Nov 30.

7

[Eukaryotic expression and biological activities of anti-p185 erbB2 mouse/human chimeric antibody].抗p185 erbB2小鼠/人嵌合抗体的真核表达及生物学活性

Beijing Da Xue Xue Bao Yi Xue Ban. 2004 Oct;36(5):491-5.

8

Anti-Her-2/neu antibody induces apoptosis in Her-2/neu overexpressing breast cancer cells independently from p53 status.抗Her-2/neu抗体可诱导Her-2/neu过表达的乳腺癌细胞凋亡，且与p53状态无关。

Br J Cancer. 2001 Nov 30;85(11):1764-70. doi: 10.1054/bjoc.2001.2197.

9

Remission of human breast cancer xenografts on therapy with humanized monoclonal antibody to HER-2 receptor and DNA-reactive drugs.使用抗HER-2受体人源化单克隆抗体和DNA反应性药物治疗后，人乳腺癌异种移植瘤的缓解情况。

Oncogene. 1998 Oct 29;17(17):2235-49. doi: 10.1038/sj.onc.1202132.

10

Biological properties of a human compact anti-ErbB2 antibody.一种人源抗ErbB2紧密抗体的生物学特性

Carcinogenesis. 2005 Nov;26(11):1890-5. doi: 10.1093/carcin/bgi146. Epub 2005 Jun 1.

引用本文的文献

1

Monoclonal antibodies as effective therapeutic agents for solid tumors.单克隆抗体作为实体瘤的有效治疗药物。

Cancer Sci. 2004 Aug;95(8):621-5. doi: 10.1111/j.1349-7006.2004.tb03319.x.

2

Prevention of gastrointestinal tumors based on adenomatous polyposis coli gene mutation by dendritic cell vaccine.基于腺瘤性息肉病大肠杆菌基因突变的树突状细胞疫苗预防胃肠道肿瘤

J Clin Invest. 2004 May;113(9):1307-17. doi: 10.1172/JCI17323.

3

Enhanced anti-tumor effect of trastuzumab in combination with cisplatin.曲妥珠单抗联合顺铂增强抗肿瘤作用。

Jpn J Cancer Res. 2002 May;93(5):574-81. doi: 10.1111/j.1349-7006.2002.tb01293.x.

本文引用的文献

1

A human/mouse chimeric monoclonal antibody against intercellular adhesion molecule-1 for tumor radioimmunoimaging.一种用于肿瘤放射免疫显像的抗细胞间黏附分子-1人/鼠嵌合单克隆抗体。

Jpn J Cancer Res. 1996 Apr;87(4):405-11. doi: 10.1111/j.1349-7006.1996.tb00237.x.

2

Differential responses of human tumor cell lines to anti-p185HER2 monoclonal antibodies.人肿瘤细胞系对抗p185HER2单克隆抗体的不同反应。

Cancer Immunol Immunother. 1993 Sep;37(4):255-63. doi: 10.1007/BF01518520.

3

Monoclonal antibodies as agonists: an expanded role for their use in cancer therapy.作为激动剂的单克隆抗体：其在癌症治疗中的应用范围扩大

Cancer Res. 1994 Oct 15;54(20):5301-9.

4

Significance of erbB-2 gene product as a target molecule for cancer therapy.

Scand J Immunol. 1994 May;39(5):459-66. doi: 10.1111/j.1365-3083.1994.tb03401.x.

5

Establishment and characterization of mouse-human chimeric monoclonal antibody to erbB-2 product.抗erbB-2产物的小鼠-人嵌合单克隆抗体的建立与鉴定

Jpn J Cancer Res. 1994 Feb;85(2):172-8. doi: 10.1111/j.1349-7006.1994.tb02079.x.

6

Monoclonal antibodies directed to the erbB-2 receptor inhibit in vivo tumour cell growth.针对erbB - 2受体的单克隆抗体可抑制体内肿瘤细胞生长。

Br J Cancer. 1993 Dec;68(6):1140-5. doi: 10.1038/bjc.1993.494.

7

Suppression and promotion of tumor growth by monoclonal antibodies to ErbB-2 differentially correlate with cellular uptake.抗ErbB-2单克隆抗体对肿瘤生长的抑制和促进作用与细胞摄取存在差异相关性。

Proc Natl Acad Sci U S A. 1995 Apr 11;92(8):3353-7. doi: 10.1073/pnas.92.8.3353.

8

Apoptosis induced by an anti-epidermal growth factor receptor monoclonal antibody in a human colorectal carcinoma cell line and its delay by insulin.

J Clin Invest. 1995 Apr;95(4):1897-905. doi: 10.1172/JCI117871.

9

Antibody-induced growth inhibition is mediated through immunochemically and functionally distinct epitopes on the extracellular domain of the c-erbB-2 (HER-2/neu) gene product p185.

Int J Cancer. 1993 Feb 1;53(3):401-8. doi: 10.1002/ijc.2910530310.

10

Prevention of breast tumour development in vivo by downregulation of the p185neu receptor.通过下调p185neu受体在体内预防乳腺肿瘤发展

Nat Med. 1995 Jul;1(7):644-8. doi: 10.1038/nm0795-644.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

文档翻译

学术文献翻译模型，支持多种主流文档格式。