Hu Q, Tang J, Liu W, Zhang G
Department of Physiology, Hubei Medical University.
Zhen Ci Yan Jiu. 1995;20(2):18-21.
Experiments were performed on 53 rats. The nociceptive discharges of spinal dorsal horn neurons were extracellularly recorded by glass microelectrodes and tested for the effects of angiotensin II (A II) on the nociceptive discharges of spinal dorsal horn neurons and AII on the inhibitory effects of electroacupuncture (EA). The results showed as follows: (a) The nociceptive discharges of spinal dorsal horn neurons might be inhibited (25/35) or facilitated (10) with A II (50-500 ng/20 ul) applied to the surface of dorsal spinal cord (L2-3); (b) The facilitory effects (5/5) were observed with A II (2 ug/20 ul) applied to the surface of dorsal spinal cord; (c) The inhibitory effects of EA (20 Hz, 2-4 V, 5 min) could be increased with A II (250 mg/20 ul, 8/9). Therefore, A II may modulate the nociceptive response of spinal dorsal horn neurons and influence the effects of EA, and different effects can be produced when the different dosage of A II is applied to the surface of dorsal horn.
对53只大鼠进行了实验。用玻璃微电极细胞外记录脊髓背角神经元的伤害性放电，并检测血管紧张素II（A II）对脊髓背角神经元伤害性放电的影响以及A II对电针（EA）抑制作用的影响。结果如下：（a）将A II（50 - 500 ng/20 μl）应用于脊髓背侧表面（L2 - 3）时，脊髓背角神经元的伤害性放电可能受到抑制（25/35）或易化（10）；（b）将A II（2 μg/20 μl）应用于脊髓背侧表面时，观察到易化作用（5/5）；（c）A II（250 μg/20 μl，8/9）可增强EA（20 Hz，2 - 4 V，5分钟）的抑制作用。因此，A II可能调节脊髓背角神经元的伤害性反应并影响EA的作用，当将不同剂量的A II应用于背角表面时可产生不同的效应。
