Hall G S, Pratt-Rippin K, Meisler D M, Washington J A, Roussel T J, Miller D
Section of Microbiology, Cleveland Clinic, OH.
Curr Eye Res. 1994 Jun;13(6):465-6. doi: 10.3109/02713689408999875.
We established growth curves for Propionibacterium acnes isolates recovered from eyes with chronic postoperative endophthalmitis. The growth curve plotted the average of the duplicate bacterial concentration against time. The generation time for P. acnes calculated from the growth curves was approximately 5.1 hours. The growth of P. acnes is slower than other anaerobic bacteria. This may account for its delayed appearance in culture of ocular specimens. It may also explain treatment failure if the concentration of an antibiotic injected into the vitreous does not remain at an effective level during the critical replicative phase of the organism.
我们建立了从慢性术后眼内炎患者眼睛中分离出的痤疮丙酸杆菌菌株的生长曲线。该生长曲线绘制了重复测量的细菌浓度平均值随时间的变化情况。根据生长曲线计算出的痤疮丙酸杆菌的代时约为5.1小时。痤疮丙酸杆菌的生长比其他厌氧菌慢。这可能解释了其在眼部标本培养中出现延迟的原因。如果在该微生物的关键复制阶段，注入玻璃体的抗生素浓度未维持在有效水平，这也可能解释治疗失败的原因。
