Aschbacher P W
J Toxicol Environ Health Suppl. 1976;1:45-59.
The metabolic fate of diethylstilbestrol (DES) in food-producing animals is described in this paper. Emphasis is on ruminant animals because DES is currently used in their production. Data presented from recent studies in ruminants show 14C excretion (rates and routes) and distribution after ingestion or subcutaneous implantation of 14C-labeled DES. The chemical nature of the radioactive compounds in excreta and liver is described. In addition, DES metabolism in cockerels and swine and degradation of DES in feces are discussed. The sources of data in this review are published studies, and a limited amount of unpublished data from the author's laboratory are included.
本文描述了己烯雌酚（DES）在食用动物体内的代谢归宿。重点是反刍动物，因为DES目前仍用于其生产中。近期反刍动物研究提供的数据显示了摄入或皮下植入14C标记的DES后的14C排泄情况（速率和途径）及分布。文中描述了排泄物和肝脏中放射性化合物的化学性质。此外，还讨论了DES在公鸡和猪体内的代谢以及DES在粪便中的降解情况。本综述的数据来源为已发表的研究，还纳入了作者实验室的少量未发表数据。
