van Bel F, van Zoeren D, Houdkamp E, Berger H M
Department of Pediatrics, Neonatal Unit, University Hospital of Leiden, The Netherlands.
Dev Pharmacol Ther. 1993;20(1-2):45-53. doi: 10.1159/000457540.
Indomethacin lowers neonatal cerebral perfusion immediately after intravenous administration. It is important to elucidate whether this reduction is mediated by inhibition of production of prostaglandins, especially prostacyclin, which plays an important role in the autoregulation of the neonatal cerebral vascular bed. We studied changes in cerebral blood flow by serial measurements of temporal mean flow velocity in the anterior cerebral artery (TMFV-ACA), relative cerebral vascular resistance (R-cer), and prostaglandins (measured as changes in thiobarbituric acid reactive substances concentration; TBARS) after a therapeutic dose of 0.1 mg/kg indomethacin administered intravenously for noninvasive closure of patent ductus arteriosus. TMFV-ACA decreased and R-cer increased immediately after the indomethacin administration with a sustained recovery to pre-indomethacin values. The TBARS concentrations, however, did not change during the study period. We conclude that the present study suggests that a therapeutic dose of 0.1 mg/kg of indomethacin has no impact on prostaglandin metabolism.
静脉注射后，吲哚美辛会立即降低新生儿的脑灌注。阐明这种降低是否由前列腺素（尤其是前列环素，其在新生儿脑血管床的自动调节中起重要作用）生成的抑制介导非常重要。我们通过连续测量大脑前动脉的颞部平均流速（TMFV-ACA）、相对脑血管阻力（R-cer）以及前列腺素（以硫代巴比妥酸反应性物质浓度的变化来衡量；TBARS），研究了静脉注射0.1mg/kg治疗剂量的吲哚美辛用于无创性闭合动脉导管未闭后，脑血流量的变化。吲哚美辛给药后，TMFV-ACA立即下降，R-cer升高，并持续恢复到给药前的值。然而，在研究期间，TBARS浓度没有变化。我们得出结论，本研究表明0.1mg/kg的治疗剂量吲哚美辛对前列腺素代谢没有影响。
