Guo S Z, Shen Q, Zhang H B
Department of Precancerous Pathology, Henan Medical University, Zhengzhou.
Zhonghua Zhong Liu Za Zhi. 1994 Mar;16(2):125-7.
The expression of IAP in the esophageal tissues of 74 patients with esophageal squamous cell carcinoma and 12 normal controls were determined by using MI2, and anti-IAP monoclonal antibody, and ABC immunohistochemical staining. The results showed that there was no expression of IAP in normal esophageal epithelium of all control subjects, and the positive rate in specimens of the esophageal carcinomas was 90.3% (P < 0.001). The staining intensity of IAP was increasing with the decrease in degrees of cell differentiation of the tumors (P < 0.05). The expression of IAP in long survivors without lymph node metastasis were lower than that in cases with metastasis (P < 0.005) and short survivors (P < 0.001). The results suggest that IAP may play an important role in tumor cell differentiation, clinical course and prognosis of esophageal carcinoma, and may be used as a tumor marker for the diagnosis of this malignancy.
采用MI2、抗IAP单克隆抗体及ABC免疫组化染色法，检测74例食管鳞状细胞癌患者食管组织及12例正常对照者食管组织中IAP的表达情况。结果显示，所有对照者正常食管上皮均无IAP表达，食管癌标本中IAP阳性率为90.3%（P<0.001）。IAP染色强度随肿瘤细胞分化程度降低而增强（P<0.05）。无淋巴结转移的长期存活者IAP表达低于有转移者（P<0.005）及短期存活者（P<0.001）。结果提示，IAP可能在食管癌的肿瘤细胞分化、临床病程及预后中起重要作用，可作为该恶性肿瘤诊断的肿瘤标志物。
