Suo Z, Su W, Holm R, Nesland J M
Department of Pathology, Norwegian Radium Hospital, Oslo, Norway.
Anticancer Res. 1995 Nov-Dec;15(6B):2797-8.
Fifty-one cases of esophageal squamous cell carcinoma were immunohistochemically investigated with monoclonal c-erbB 2 oncoprotein antibody. No tumor showed plasma membrane immunostaining for c-erbB-2 protein. Occasionally, unspecific cytoplasmic staining was found in minor tumor cell populations. The present results show that c-erbB-2 oncoprotein is not overexpressed in esophageal squamous cell carcinomas and does not play a central role in the tumorigenesis.
应用单克隆c-erbB 2癌蛋白抗体对51例食管鳞状细胞癌进行免疫组织化学研究。无一例肿瘤显示c-erbB-2蛋白的细胞膜免疫染色。偶尔，在少数肿瘤细胞群体中发现非特异性细胞质染色。目前的结果表明，c-erbB-2癌蛋白在食管鳞状细胞癌中未过度表达，在肿瘤发生中不发挥核心作用。
