Miyazaki M, Hashimoto T, Fujii E, Tayama M, Kuroda Y
Department of Pediatrics, Tokushima University School of Medicine, Japan.
Epilepsia. 1994 Sep-Oct;35(5):988-92. doi: 10.1111/j.1528-1157.1994.tb02543.x.
Ten infantile spasms (IS) patients had single photon emission computed tomography (SPECT) with [99mTc]HMPAO, EEG, and magnetic resonance imaging (MRI) studies. SPECT showed localized cerebral hypoperfusion in 7 infants (4 unifocal; 3 multifocal) always involving the temporal regions either unilaterally or bilaterally. EEGs obtained in near time of the SPECT studies showed focal abnormalities in all 7 infants with hypoperfusion on SPECT, with complete correspondence of the abnormalities in 5. MRI showed localized cerebral lesions in only 3 of the 10 infants, all of whom had corresponding areas of hypoperfusion on SPECT. Our study indicates that localized cerebral abnormalities (especially of the temporal lobes) may often be associated with IS and that such patients may have localized cerebral hypoperfusion on SPECT even when the MRI is normal.
十名婴儿痉挛症（IS）患者接受了[99mTc]HMPAO单光子发射计算机断层扫描（SPECT）、脑电图（EEG）和磁共振成像（MRI）检查。SPECT显示7名婴儿（4名单发灶性；3名多发灶性）存在局限性脑灌注不足，总是单侧或双侧累及颞叶区域。在SPECT检查临近时间进行的脑电图显示，所有7名SPECT显示灌注不足的婴儿均存在局灶性异常，其中5名婴儿的异常完全对应。MRI仅在10名婴儿中的3名显示有局限性脑病变，所有这些婴儿在SPECT上均有相应的灌注不足区域。我们的研究表明，局限性脑异常（尤其是颞叶）可能常与婴儿痉挛症相关，并且即使MRI正常，此类患者在SPECT上也可能存在局限性脑灌注不足。
