Morgan D L, Dunnick J K, Goehl T, Jokinen M P, Matthews H B, Zeiger E, Mennear J H
National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709.
Environ Health Perspect. 1994 Jun;102 Suppl 2(Suppl 2):63-78. doi: 10.1289/ehp.9410263.
The benzidine dye initiative is a research program established by the National Toxicology Program to generate an integrated body of scientific information regarding the potential health risks associated with exposure to benzidine- and benzidine-congener-derived dyes. Because an in-depth evaluation of each of the hundreds of benzidine-congener-derived dyes was considered impractical, the research program was designed to study the metabolism and disposition, genetic toxicity, and in vivo toxicity and carcinogenicity of two primary benzidine congeners, 3,3'-dimethylbenzidine and 3,3'-dimethoxybenzidine, and a select group of prototypical dyes derived from those amines. It was anticipated that by applying the basic information generated in these extensive studies, it would be possible to make regulatory decisions about other dyes after conducting only a minimal number of experiments such as studies of disposition and metabolism, and in vitro mutagenicity. This paper summarizes the results of studies conducted to evaluate the metabolism, disposition, mutagenicity, toxicity, and carcinogenicity of representative benzidine congeners and derived dyes.
联苯胺染料计划是美国国家毒理学计划设立的一个研究项目，旨在收集关于接触联苯胺及其同系物衍生染料可能带来的健康风险的综合科学信息。由于对数百种联苯胺同系物衍生染料逐一进行深入评估被认为不切实际，该研究项目旨在研究两种主要联苯胺同系物3,3'-二甲基联苯胺和3,3'-二甲氧基联苯胺以及从这些胺类衍生出的一组典型染料的代谢与处置、遗传毒性、体内毒性和致癌性。预计通过应用这些广泛研究中产生的基础信息，在仅进行少量实验（如处置和代谢研究以及体外诱变性研究）之后，就有可能对其他染料做出监管决策。本文总结了为评估代表性联苯胺同系物及其衍生染料的代谢、处置、诱变性、毒性和致癌性而开展的研究结果。
