White I M, Miller D P, White W, Dike G L, Rebec G V, Steinmetz J E
Department of Psychology, Indiana University, Bloomington 47405.
Exp Brain Res. 1994;99(2):179-90. doi: 10.1007/BF00239585.
Extracellular multiple- and single-unit recordings were made from the neostriatum of rabbits during classical eyelid conditioning. Neostriatal neurons processed information regarding the conditioned auditory stimulus (CS) and conditioned eyelid response (CR) as well as the unconditioned stimulus/response (US/UR). These data are consistent with previous reports that neostriatal neurons respond to movement and movement-related sensory stimuli. In most cases, neostriatal neurons increased activity to the US during the early phase of training, but to the CR as training progressed. A close temporal correlation was found between neuronal activity and CR onset with unit discharges typically preceding CR onset by 10-50 ms. The activity of some multiple and single units was monitored after injection of haloperidol, a neuroleptic and dopamine antagonist known to disrupt neostriatal function. Interestingly, haloperidol caused a greater disruption of CRs at low-intensity than at high-intensity CSs, but conditioning-related neuronal activity was disrupted equally at both intensities. These data are discussed in terms of a possible role for the neostriatum in eyelid conditioning.
在经典眼睑条件反射过程中，对家兔新纹状体进行了细胞外多单位和单单位记录。新纹状体神经元处理有关条件性听觉刺激（CS）、条件性眼睑反应（CR）以及非条件刺激/反应（US/UR）的信息。这些数据与之前关于新纹状体神经元对运动及与运动相关的感觉刺激有反应的报道一致。在大多数情况下，新纹状体神经元在训练早期对US增加活动，但随着训练进展对CR增加活动。发现神经元活动与CR起始之间存在紧密的时间相关性，单位放电通常在CR起始前10 - 50毫秒。在注射氟哌啶醇后监测了一些多单位和单单位的活动，氟哌啶醇是一种已知会破坏新纹状体功能的抗精神病药物和多巴胺拮抗剂。有趣的是，氟哌啶醇在低强度CS时比在高强度CS时对CR的破坏更大，但在两种强度下与条件反射相关的神经元活动均受到同等程度的破坏。根据新纹状体在眼睑条件反射中可能的作用对这些数据进行了讨论。
