White I M, Rebec G V
Department of Psychology, Indiana University, Bloomington 47405.
Brain Res. 1993 Jul 9;616(1-2):71-82. doi: 10.1016/0006-8993(93)90194-r.
Neural activity was recorded from 218 sites in the striatum (caudate-putamen and nucleus accumbens) of rats trained on a lever-release version of the conditioned avoidance response (CAR) task, in which an auditory signal elicits a short-latency, forelimb withdrawal. > 80% of these recording sites showed task-related activity, including neurons that responded to the auditory stimulus (signal-related cells), the lever-release (response-related cells), or both of these events (signal/response-related cells). Histological analysis revealed a predominance of signal-related neurons in medial striatum, whereas lateral recording sites mainly showed response-related activity. Haloperidol (0.1 mg/kg s.c.), a widely used neuroleptic that impairs CAR performance, significantly attenuated task-related neural activity without altering the latency of the neural response or spontaneous firing rate. Collectively, these results, which demonstrate the usefulness of the lever-release CAR paradigm for assessing striatal function, suggest that the sensory and motor aspects of the CAR task are processed by different striatal regions. Moreover, haloperidol appears to disrupt the striatal processing of both sensory and motor information.
在经过条件性回避反应（CAR）任务杠杆释放版本训练的大鼠纹状体（尾状核-壳核和伏隔核）的218个位点记录神经活动，在该任务中，听觉信号引发短潜伏期的前肢撤回。这些记录位点中超过80%显示出与任务相关的活动，包括对听觉刺激做出反应的神经元（信号相关细胞）、杠杆释放（反应相关细胞）或这两个事件（信号/反应相关细胞）。组织学分析显示，内侧纹状体中信号相关神经元占主导，而外侧记录位点主要显示反应相关活动。氟哌啶醇（0.1mg/kg皮下注射）是一种广泛使用的抗精神病药物，会损害CAR表现，它能显著减弱与任务相关的神经活动，而不改变神经反应的潜伏期或自发放电率。总体而言，这些结果证明了杠杆释放CAR范式在评估纹状体功能方面的有用性，表明CAR任务的感觉和运动方面由不同的纹状体区域处理。此外，氟哌啶醇似乎会干扰纹状体对感觉和运动信息的处理。
