Van Gelder T, Damhuis R A, Hoogsteden H C
Dept of Internal Medicine I, University Hospital Rotterdam, The Netherlands.
Eur Respir J. 1994 Jun;7(6):1035-8.
Malignant pleural mesothelioma is a lethal disease and little is known about prognostic factors. The prognostic significance of age, stage of disease, gender and histological subtype was studied in 167 new cases of cytologically (15%) or histologically (85%) proven malignant pleural mesothelioma in the Rotterdam area, during the period 1987-1989. Median survival of all patients was 242 days. Univariate analysis identified age, stage and histopathological subtype as significant prognostic factors, which was confirmed in multivariate analysis. Median survival rates for patients < 65, 65-74 and > or = 75 yrs were 359, 242 and 131 days, respectively. Patients with Stage I disease had a median survival of 359 days compared to 147 and 112 days, respectively, for patients with Stage II and the combination of Stages III and IV. Mixed histopathological subtype (190 days) was less favourable than sarcomatous (207 days) and epithelial (252 days) subtypes. Using a Cox proportional hazard model in patients with malignant pleural mesothelioma, age, histological subtype and stage were identified as independent prognostic factors. These prognostic factors should be taken into account when starting or evaluating treatment studies.
恶性胸膜间皮瘤是一种致命疾病，关于其预后因素人们知之甚少。在1987年至1989年期间，对鹿特丹地区167例经细胞学（15%）或组织学（85%）证实的恶性胸膜间皮瘤新病例，研究了年龄、疾病分期、性别和组织学亚型的预后意义。所有患者的中位生存期为242天。单因素分析确定年龄、分期和组织病理学亚型为显著的预后因素，多因素分析证实了这一点。年龄＜65岁、65 - 74岁和≥75岁患者的中位生存期分别为359天、242天和131天。I期疾病患者的中位生存期为359天，而II期以及III期和IV期合并患者的中位生存期分别为147天和112天。混合组织病理学亚型（190天）的预后不如肉瘤样（207天）和上皮样（252天）亚型。在恶性胸膜间皮瘤患者中使用Cox比例风险模型，确定年龄、组织学亚型和分期为独立的预后因素。在启动或评估治疗研究时应考虑这些预后因素。
