去铁胺对实验性蛛网膜下腔出血后脑脂质过氧化物水平和钠钾ATP酶活性的影响

The effect of deferoxamine on brain lipid peroxide levels and Na-K ATPase activity following experimental subarachnoid hemorrhage.

Bilgihan A, Türközkan N, Aricioğlu A, Aykol S, Cevik C, Göksel M

Department of Biochemistry, Gazi University, Medical Faculty, Ankara, Turkey.

Gen Pharmacol. 1994 May;25(3):495-7. doi: 10.1016/0306-3623(94)90204-6.

Abstract

In the present study we have studied the effects of deferoxamine treatment on lipid peroxidation and Na-K ATPase activity after experimental induction of subarachnoid haemorrhage (SAH) in guinea pigs. 2. We assessed the extent of lipid peroxidation by measuring the level of malondialdehyde and Na-K ATPase activity in 3 different groups (sham-operated, SAH, SAH + deferoxamine). 3. There was no significant difference in lipid peroxide content between sham-operated and haemorrhagic animals, but Na-K ATPase activity decreased after SAH. 4. Deferoxamine treatment reduced the malondialdehyde content and induced the recovery of Na-K ATPase activity, exerting a brain protective role against the detrimental effects of the haemorrhage.

摘要

在本研究中，我们研究了去铁胺治疗对豚鼠实验性蛛网膜下腔出血（SAH）后脂质过氧化和钠钾ATP酶活性的影响。2. 我们通过测量丙二醛水平和钠钾ATP酶活性，在3个不同组（假手术组、SAH组、SAH+去铁胺组）中评估脂质过氧化程度。3. 假手术组和出血动物之间的脂质过氧化物含量无显著差异，但SAH后钠钾ATP酶活性降低。4. 去铁胺治疗降低了丙二醛含量，并诱导钠钾ATP酶活性恢复，对出血的有害影响发挥脑保护作用。