Haas H, Schlaak M
Medizinische Klinik, Forschungsinstitut Borstel.
Immun Infekt. 1994 Jun;22(3):88-93.
T helper type 2 (TH2) cells are a major source of interleukin- (IL-)4 which plays a critical role in the induction of the IgE synthesis. Their counterplayers, the T helper type 1 (TH1) cells produce interferon- (IFN-)gamma which inhibits the IL-4-induced IgE synthesis. Thus, the TH2/TH1 ratio plays an important role in the regulation of the IgE synthesis. Moreover, IL-4 seems to be the crucial factor controlling the switch of T helper precursor (THp) cells to the TH2 phenotype. However, the primary cellular source of IL-4 that skews an immune response towards the TH2 phenotype is not yet known. For future prophylactic and therapeutic interventions, e.g. in allergy, it will be crucial to know the type of cell involved and the factors that are activating this cell, i.e. the exact mechanism that is controlling the switch to the TH2 phenotype.
2型辅助性T细胞（TH2细胞）是白细胞介素-4（IL-4）的主要来源，IL-4在诱导IgE合成中起关键作用。它们的对手，1型辅助性T细胞（TH1细胞）产生γ干扰素（IFN-γ），抑制IL-4诱导的IgE合成。因此，TH2/TH1比值在IgE合成的调节中起重要作用。此外，IL-4似乎是控制辅助性T前体细胞（THp）向TH2表型转变的关键因素。然而，使免疫反应偏向TH2表型的IL-4的主要细胞来源尚不清楚。对于未来的预防性和治疗性干预措施，例如在过敏治疗中，了解涉及的细胞类型以及激活该细胞的因素，即控制向TH2表型转变的确切机制至关重要。
