表达γδ T细胞抗原受体的小鼠T淋巴细胞有助于在体内抵抗沙门氏菌感染。
Mouse T lymphocytes that express a gamma delta T-cell antigen receptor contribute to resistance to Salmonella infection in vivo.
作者信息
Mixter P F, Camerini V, Stone B J, Miller V L, Kronenberg M
机构信息
Department of Microbiology and Immunology, UCLA School of Medicine.
出版信息
Infect Immun. 1994 Oct;62(10):4618-21. doi: 10.1128/iai.62.10.4618-4621.1994.
Abstract
Mice depleted of lymphocytes expressing the alpha beta or the gamma delta T-cell receptor for antigen (TCR) by antibody treatment were infected orally with Salmonella enteritidis. In both groups of treated mice, the 50% lethal dose decreased, suggesting that both the alpha beta TCR+ and the gamma delta TCR+ subsets contribute to resistance to oral infection. These data provide further evidence for the contribution of gamma delta T cells in the response to bacterial infections.
摘要
通过抗体处理使表达抗原αβ或γδ T细胞受体（TCR）的淋巴细胞耗竭的小鼠经口感染肠炎沙门氏菌。在两组经处理的小鼠中，50%致死剂量均降低，这表明αβ TCR+和γδ TCR+亚群均有助于抵抗经口感染。这些数据为γδ T细胞在细菌感染应答中的作用提供了进一步的证据。
相似文献
1
Mouse T lymphocytes that express a gamma delta T-cell antigen receptor contribute to resistance to Salmonella infection in vivo.表达γδ T细胞抗原受体的小鼠T淋巴细胞有助于在体内抵抗沙门氏菌感染。
Infect Immun. 1994 Oct;62(10):4618-21. doi: 10.1128/iai.62.10.4618-4621.1994.
2
A protective role of extrathymic alpha beta TcR cells in the liver in primary murine salmonellosis.胸腺外αβT细胞受体细胞在小鼠原发性沙门氏菌病肝脏中的保护作用
Immunology. 1994 Jan;81(1):8-14.
3
4
IL-17A is produced by Th17, gammadelta T cells and other CD4- lymphocytes during infection with Salmonella enterica serovar Enteritidis and has a mild effect in bacterial clearance.在感染肠炎沙门氏菌血清型肠炎菌株期间，白细胞介素-17A由辅助性T细胞17、γδT细胞及其他CD4淋巴细胞产生，在细菌清除方面作用轻微。
Int Immunol. 2008 Sep;20(9):1129-38. doi: 10.1093/intimm/dxn069. Epub 2008 Jul 3.
5
6
Immunoregulatory functions for murine intraepithelial lymphocytes: gamma/delta T cell receptor-positive (TCR+) T cells abrogate oral tolerance, while alpha/beta TCR+ T cells provide B cell help.小鼠上皮内淋巴细胞的免疫调节功能：γ/δ T细胞受体阳性（TCR+）T细胞消除口服耐受性，而α/β TCR+ T细胞提供B细胞辅助。
J Exp Med. 1992 Mar 1;175(3):695-707. doi: 10.1084/jem.175.3.695.
7
Cross-talk between V beta 8+ and gamma delta+ T lymphocytes in contact sensitivity.接触性超敏反应中Vβ8 +和γδ + T淋巴细胞之间的相互作用
Immunology. 1998 Apr;93(4):469-77. doi: 10.1046/j.1365-2567.1998.00435.x.
8
Different appearance of gamma delta T cells during salmonellosis between Ityr and Itys mice.肠炎沙门氏菌感染期间，Ityr和Itys小鼠体内γδ T细胞的不同表现。
J Immunol. 1993 Apr 15;150(8 Pt 1):3411-20.
9
10
Cytolytic activity of intestinal intraepithelial lymphocytes in germ-free mice is strain dependent and determined by T cells expressing gamma delta T-cell antigen receptors.无菌小鼠肠道上皮内淋巴细胞的细胞溶解活性具有品系依赖性，且由表达γδ T细胞抗原受体的T细胞决定。
Proc Natl Acad Sci U S A. 1993 Sep 15;90(18):8591-4. doi: 10.1073/pnas.90.18.8591.
引用本文的文献
1
Dynamic Changes in the Intraepithelial Lymphocyte Numbers Following Typhimurium Infection in Broiler Chickens.肉鸡感染鼠伤寒沙门氏菌后上皮内淋巴细胞数量的动态变化
Animals (Basel). 2024 Nov 30;14(23):3463. doi: 10.3390/ani14233463.
2
Regulation of Synovial γδ T Cell Ligand Expression by Mitochondrial Reactive Oxygen Species and Gasdermin-D.滑膜γδ T 细胞配体表达的调控由线粒体活性氧和 Gasdermin-D 介导。
J Immunol. 2023 Jan 1;210(1):61-71. doi: 10.4049/jimmunol.2101166.
3
T-Cell Cytokine Response in Typhimurium-Vaccinated versus Infected Pigs.鼠伤寒沙门氏菌疫苗接种猪与感染猪的T细胞细胞因子反应
Vaccines (Basel). 2021 Aug 2;9(8):845. doi: 10.3390/vaccines9080845.
4
Mannose-Modified Chitosan-Nanoparticle-Based Subunit OralVaccine-Induced Immune Response and Efficacy in a Challenge Trial in Broilers.基于甘露糖修饰壳聚糖纳米颗粒的亚单位口服疫苗在肉鸡攻毒试验中的免疫应答及效果
Vaccines (Basel). 2020 Jun 11;8(2):299. doi: 10.3390/vaccines8020299.
5
Detection of Cell Surface Ligands for Human Synovial γδ T Cells.检测人滑膜 γδ T 细胞的细胞表面配体。
J Immunol. 2019 Nov 1;203(9):2369-2376. doi: 10.4049/jimmunol.1900451. Epub 2019 Sep 23.
6
Vaccination against Salmonella Infection: the Mucosal Way.沙门氏菌感染的疫苗接种：黏膜途径。
Microbiol Mol Biol Rev. 2017 Jun 14;81(3). doi: 10.1128/MMBR.00007-17. Print 2017 Sep.
7
γδ T Cells and dendritic cells in refractory Lyme arthritis.难治性莱姆关节炎中的γδ T细胞与树突状细胞
J Leukoc Biol. 2015 Apr;97(4):653-63. doi: 10.1189/jlb.2RU0714-343RR. Epub 2015 Jan 20.
8
Cellular requirements for systemic control of Salmonella enterica serovar Typhimurium infections in mice.小鼠中系统性控制肠炎沙门氏菌鼠伤寒血清型感染的细胞需求。
Infect Immun. 2014 Dec;82(12):4997-5004. doi: 10.1128/IAI.02192-14. Epub 2014 Sep 15.
9
Intestinal intraepithelial lymphocyte-enterocyte crosstalk regulates production of bactericidal angiogenin 4 by Paneth cells upon microbial challenge.肠上皮内淋巴细胞-肠细胞相互作用调节潘氏细胞在微生物挑战时产生杀菌性血管生成素 4。
PLoS One. 2013 Dec 17;8(12):e84553. doi: 10.1371/journal.pone.0084553. eCollection 2013.
10
Small intestinal intraepithelial lymphocytes expressing CD8 and T cell receptor γδ are involved in bacterial clearance during Salmonella enterica serovar Typhimurium infection.表达 CD8 和 T 细胞受体 γδ 的小肠上皮内淋巴细胞参与鼠伤寒沙门氏菌感染期间的细菌清除。
Infect Immun. 2012 Feb;80(2):565-74. doi: 10.1128/IAI.05078-11. Epub 2011 Dec 5.
本文引用的文献
1
Listeria monocytogenes-induced gamma interferon secretion by intestinal intraepithelial gamma/delta T lymphocytes.单核细胞增生李斯特菌诱导肠道上皮γ/δ T淋巴细胞分泌γ干扰素
Infect Immun. 1993 May;61(5):2154-61. doi: 10.1128/iai.61.5.2154-2161.1993.
2
Different appearance of gamma delta T cells during salmonellosis between Ityr and Itys mice.肠炎沙门氏菌感染期间，Ityr和Itys小鼠体内γδ T细胞的不同表现。
J Immunol. 1993 Apr 15;150(8 Pt 1):3411-20.
3
Induction of murine peritoneal gamma/delta T cells and their role in resistance to bacterial infection.小鼠腹膜γ/δ T细胞的诱导及其在抵抗细菌感染中的作用。
J Exp Med. 1993 Sep 1;178(3):971-84. doi: 10.1084/jem.178.3.971.
4
Antigens recognized by gamma delta T cells.γδ T细胞识别的抗原。
Curr Opin Immunol. 1994 Feb;6(1):64-71. doi: 10.1016/0952-7915(94)90035-3.
5
Monoclonal antibodies specific to native murine T-cell receptor gamma delta: analysis of gamma delta T cells during thymic ontogeny and in peripheral lymphoid organs.针对天然小鼠T细胞受体γδ的单克隆抗体：胸腺发育过程中和外周淋巴器官中γδ T细胞的分析
Proc Natl Acad Sci U S A. 1989 Jul;86(13):5094-8. doi: 10.1073/pnas.86.13.5094.
6
The structure, function, and molecular genetics of the gamma/delta T cell receptor.γ/δ T细胞受体的结构、功能及分子遗传学
Annu Rev Immunol. 1989;7:175-207. doi: 10.1146/annurev.iy.07.040189.001135.
7
A TCR gamma delta cell recognizing a novel TL-encoded gene product.一个识别新的TL编码基因产物的TCRγδ细胞。
Cold Spring Harb Symp Quant Biol. 1989;54 Pt 1:45-55. doi: 10.1101/sqb.1989.054.01.006.
8
Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures.抗CD3/T细胞受体复合物抗体可诱导胸腺培养物中未成熟T细胞发生凋亡而死亡。
Nature. 1989 Jan 12;337(6203):181-4. doi: 10.1038/337181a0.
9
Characterization of a monoclonal antibody which detects all murine alpha beta T cell receptors.一种可检测所有小鼠αβ T细胞受体的单克隆抗体的特性分析。
J Immunol. 1989 Apr 15;142(8):2736-42.
10
Extrathymic tolerance of mature T cells: clonal elimination as a consequence of immunity.成熟T细胞的胸腺外耐受：作为免疫结果的克隆清除。
Cell. 1990 Dec 21;63(6):1249-56. doi: 10.1016/0092-8674(90)90420-j.
Zotero 插件