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表达γδ T细胞抗原受体的小鼠T淋巴细胞有助于在体内抵抗沙门氏菌感染。

Mouse T lymphocytes that express a gamma delta T-cell antigen receptor contribute to resistance to Salmonella infection in vivo.

作者信息

Mixter P F, Camerini V, Stone B J, Miller V L, Kronenberg M

机构信息

Department of Microbiology and Immunology, UCLA School of Medicine.

出版信息

Infect Immun. 1994 Oct;62(10):4618-21. doi: 10.1128/iai.62.10.4618-4621.1994.

DOI:10.1128/iai.62.10.4618-4621.1994
PMID:7927728
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC303151/
Abstract

Mice depleted of lymphocytes expressing the alpha beta or the gamma delta T-cell receptor for antigen (TCR) by antibody treatment were infected orally with Salmonella enteritidis. In both groups of treated mice, the 50% lethal dose decreased, suggesting that both the alpha beta TCR+ and the gamma delta TCR+ subsets contribute to resistance to oral infection. These data provide further evidence for the contribution of gamma delta T cells in the response to bacterial infections.

摘要

通过抗体处理使表达抗原αβ或γδ T细胞受体（TCR）的淋巴细胞耗竭的小鼠经口感染肠炎沙门氏菌。在两组经处理的小鼠中，50%致死剂量均降低，这表明αβ TCR+和γδ TCR+亚群均有助于抵抗经口感染。这些数据为γδ T细胞在细菌感染应答中的作用提供了进一步的证据。

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本文引用的文献

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Listeria monocytogenes-induced gamma interferon secretion by intestinal intraepithelial gamma/delta T lymphocytes.单核细胞增生李斯特菌诱导肠道上皮γ/δ T淋巴细胞分泌γ干扰素
Infect Immun. 1993 May;61(5):2154-61. doi: 10.1128/iai.61.5.2154-2161.1993.
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Different appearance of gamma delta T cells during salmonellosis between Ityr and Itys mice.肠炎沙门氏菌感染期间，Ityr和Itys小鼠体内γδ T细胞的不同表现。
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