Karimi Newsha, Samiee Negin, Moradi Yousef
Student Research Committee, Facualty of Dentistry Kurdistan University of Medical Sciences Sanandaj Iran.
Oral and Maxillofacial Medicine Department, Facualty of Dentistry Kurdistan University of Medical Sciences Sanandaj Iran.
Health Sci Rep. 2023 Oct 19;6(10):e1630. doi: 10.1002/hsr2.1630. eCollection 2023 Oct.
The aim of this meta-analysis was to find the association between periodontal disease (PD) and the risk of adverse pregnancy outcomes, including Pre-eclampsia (PE), premature rupture of the amniotic sac, gestational diabetes (GDM), or low birth weight (LBW) in pregnant women, which should be investigated in a systematic meta-analysis.
Studies that reported the association between PD and pregnancy or neonatal outcomes and were published from January 1990 to December 2022, were identified by an extensive search in PubMed (Medline), Scopus, Web of Sciences, and Medline (Elsevier). After retrieving the studies, the screening stage was performed based on their titles, abstracts, and full texts, and after selecting the final articles, their information was extracted and their quality was assessed using the Newcastle Ottawa Scale checklist.
Pregnant women with PD had a 1.39 higher chance of developing GDM than those who did not have the infection (risk ratio [RR]: 1.39; 95% confidence interval [CI]: 1.21-1.61; I square: 49.67%; : 0.03). Additionally, the pooled RR of LBW was 2.19, which indicates that pregnant women with PD had a 2.19-fold higher risk of LBW than pregnant women who do not have the infection (RR: 2.19; 95% CI: 1.82-2.64; I square: 0.00%; : 0.65). The relationship between the risk of PE and the existence of PD was examined in 33 cohort and case-control studies for this meta-analysis. These results were combined, and the pooled RR was 1.43. This indicates that pregnant women with PD are 1.43 times more likely to experience PE than pregnant women without PD (RR: 1.43; 95% CI: 1.32-1.54; I square: 82.64%; : 0.00).
According to the findings of the current meta-analysis, PD may contribute to a higher risk of poor maternal and newborn outcomes in pregnant women.
本荟萃分析旨在探究牙周疾病（PD）与不良妊娠结局风险之间的关联，这些不良妊娠结局包括孕妇子痫前期（PE）、胎膜早破、妊娠期糖尿病（GDM）或低出生体重（LBW），需要通过系统的荟萃分析进行研究。
通过在PubMed（Medline）、Scopus、科学网和Medline（爱思唯尔）上广泛检索，确定了1990年1月至2022年12月发表的报告PD与妊娠或新生儿结局之间关联的研究。检索到研究后，根据标题、摘要和全文进行筛选阶段，选择最终文章后，提取其信息并使用纽卡斯尔渥太华量表清单评估其质量。
患有PD的孕妇患GDM的几率比未感染的孕妇高1.39倍（风险比[RR]：1.39；95%置信区间[CI]：1.21 - 1.61；I²：49.67%；P：0.03）。此外，低出生体重的合并RR为2.19，这表明患有PD的孕妇发生低出生体重的风险比未感染的孕妇高2.19倍（RR：2.19；95% CI：1.82 - 2.64；I²：0.00%；P：0.65）。在本荟萃分析的33项队列研究和病例对照研究中，研究了子痫前期风险与PD存在之间的关系。将这些结果合并，合并RR为1.43。这表明患有PD的孕妇发生子痫前期的可能性是未患PD孕妇的1.43倍（RR：1.43；95% CI：1.32 - 1.54；I²：82.64%；P：0.00）。
根据当前荟萃分析的结果，PD可能导致孕妇出现更高的母婴不良结局风险。
