白癜风中的黑素细胞储库
Melanocyte reservoir in vitiligo.
作者信息
Arrunátegui A, Arroyo C, Garcia L, Covelli C, Escobar C, Carrascal E, Falabella R
机构信息
Department of Internal Medicine, Hospital Universitario del Valle, Universidad del Valle, Cali, Colombia.
出版信息
Int J Dermatol. 1994 Jul;33(7):484-7. doi: 10.1111/j.1365-4362.1994.tb02860.x.
BACKGROUND
Dopa-negative, inactive melanocytes, present in the middle portion of the hair follicle, but also in hair bulbs, have been reported as a source of pigment cells, when repopulation of epidermal melanocytes occurs. A melanocyte reservoir in these anatomical sites has been suggested. Our objective was to investigate the ability of the lower third of the hair follicle (hair bulb) to repigment achromic skin in vitiligo.
METHODS
Scalp hair bulbs were transplanted within leukodermic areas in 10 patients with vitiligo.
RESULTS
Repigmentation around the grafts was suitable for evaluation in four cases. Dopa-positive (+) cells were seen in the epidermal basal cell layer of the repigmented areas.
CONCLUSIONS
Although these findings were observed only in a few patients, they suggest that melanocytes from the implanted lower third portion of the hair follicle (hair bulb) act as a reservoir in this anatomic location and are able to migrate and repigment achromic areas in vitiligo.
背景
据报道，存在于毛囊中部但也存在于毛球中的多巴阴性、无活性黑素细胞，在表皮黑素细胞重新填充时是色素细胞的来源。有人提出在这些解剖部位存在黑素细胞库。我们的目的是研究毛囊下三分之一（毛球）在白癜风中使色素脱失皮肤重新色素沉着的能力。
方法
将头皮毛球移植到10例白癜风患者的白斑区域内。
结果
4例患者移植部位周围的色素沉着适合评估。在色素沉着区域的表皮基底层可见多巴阳性（+）细胞。
结论
虽然仅在少数患者中观察到这些结果，但它们表明，植入的毛囊下三分之一部分（毛球）中的黑素细胞在这个解剖位置起到了储存库的作用，并且能够迁移并使白癜风中的色素脱失区域重新色素沉着。
Zotero 插件