Nakadate T, Sato T, Kagawa J, Yagami T
Department of Hygiene and Public Health, Tokyo Women's Medical College, Japan.
Ind Health. 1994;32(1):29-40. doi: 10.2486/indhealth.32.29.
A cross-sectional analysis on the dose-related change in time domain spirogram indices induced by lifetime cigarette consumption was conducted to examine the ability of those indices to detect early changes in the lung periphery in comparison with conventional spirometric indices. The subjects were asymptomatic healthy male workers from three occupational cohorts including asbestos workers and welders. They were asked to perform the forced expiration maneuver at least three times to obtain reliable results. A total of 893 subjects were enrolled in the study, and 484 of them who were aged 30 years or more and were free from chronic respiratory symptoms and abnormalities in chest radiography and spirometry, were analyzed. Although conventional indices, such as forced expiratory volume in one second and maximal midexpiratory flow, were not significantly different between smokers and nonsmokers, the standard deviation of transit times and of time constant distribution in smokers were significantly elevated compared with nonsmokers. Furthermore a dose-related change according to lifetime cigarette consumption was observed in those indices. We conclude that time domain spirogram indices, especially the standard deviation of time constant distribution, would be more useful than conventional indices in detecting early changes in the lung periphery.
进行了一项横断面分析，以研究终生吸烟量引起的时域肺量图指标的剂量相关变化，从而与传统肺量计指标相比，检验这些指标检测肺外周早期变化的能力。研究对象为来自三个职业队列（包括石棉工人和焊工）的无症状健康男性工人。要求他们至少进行三次用力呼气动作以获得可靠结果。共有893名受试者参与了该研究，其中484名年龄在30岁及以上，且无慢性呼吸道症状、胸部X线检查和肺量计检查异常的受试者进行了分析。尽管吸烟者和非吸烟者之间的传统指标，如一秒用力呼气量和最大呼气中期流速，没有显著差异，但吸烟者的传输时间标准差和时间常数分布标准差与非吸烟者相比显著升高。此外，在这些指标中观察到了根据终生吸烟量的剂量相关变化。我们得出结论，时域肺量图指标，尤其是时间常数分布标准差，在检测肺外周早期变化方面比传统指标更有用。
