胃泌素受体基因在几种人类癌症中的表达。
Gastrin receptor gene expression in several human carcinomas.
作者信息
Matsushima Y, Kinoshita Y, Nakata H, Inomoto-Naribayashi Y, Asahara M, Kawanami C, Nakamura A, Ito M, Matsui T, Fujiwara T
机构信息
Division of Gerontology, Kobe University School of Medicine.
出版信息
Jpn J Cancer Res. 1994 Aug;85(8):819-24. doi: 10.1111/j.1349-7006.1994.tb02953.x.
Gastrin has been shown to enhance the growth of various human tumors. The present study was designed to examine the gastrin receptor gene expression in various human carcinoma cell lines and in surgically resected carcinoma tissues. By Northern blot analysis, gastrin receptor mRNA was detected in 3 out of 7 small cell lung carcinoma cell lines. Gastrin receptor mRNA was also expressed in one out of 8 colon carcinoma cell lines and 2 out of 10 colon carcinoma tissues. Moreover, one of two small cell carcinoma cell lines of the stomach clearly expressed gastrin receptor mRNA. However, none of the gastric adenocarcinoma cell lines or surgically resected gastric adenocarcinomas tested had any detectable expression of gastrin receptor gene. These findings may suggest a role of gastrin receptor in the growth and differentiation of certain human carcinomas.
胃泌素已被证明可促进多种人类肿瘤的生长。本研究旨在检测胃泌素受体基因在多种人类癌细胞系及手术切除的癌组织中的表达情况。通过Northern印迹分析，在7个小细胞肺癌细胞系中的3个检测到胃泌素受体mRNA。在8个结肠癌细胞系中的1个以及10个结肠癌组织中的2个也表达胃泌素受体mRNA。此外，两个胃小细胞癌细胞系中的一个明显表达胃泌素受体mRNA。然而，所检测的胃腺癌细胞系或手术切除的胃腺癌均未检测到胃泌素受体基因的表达。这些发现可能提示胃泌素受体在某些人类癌的生长和分化中起作用。
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