Nocathiacins, new thiazolyl peptide antibiotics from Nocardia sp. II. Isolation, characterization, and structure determination.
作者信息
Leet John E, Li Wenying, Ax Helen A, Matson James A, Huang Stella, Huang Ron, Cantone Joseph L, Drexler Dieter, Dalterio Richard A, Lam Kin S
机构信息
Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, Connecticut 06492, USA.
出版信息
J Antibiot (Tokyo). 2003 Mar;56(3):232-42. doi: 10.7164/antibiotics.56.232.
PMID:12760679
Abstract
A new group of thiazolyl peptide antibiotics, the nocathiacins, was isolated from cultured broth of Nocardia sp. The major analogs nocathiacins I-III (1-3) were purified using silica gel and Sephadex LH-20 chromatography techniques. The structures of nocathiacins I-III were determined by spectroscopic (2D-NMR, MSn) methods, and share structural similarities to glycothiohexide-alpha (4).
摘要
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