新型萘啶霉素类抗肿瘤抗生素达纳辛A1和B1的结构

Structures of dnacin A1 and B1, new naphthyridinomycin-type antitumor antibiotics.

作者信息

Hida T, Muroi M, Tanida S, Harada S

机构信息

Discovery Research Laboratories II, Takeda Chemical Industries, Ltd., Osaka, Japan.

出版信息

J Antibiot (Tokyo). 1994 Aug;47(8):917-21. doi: 10.7164/antibiotics.47.917.

DOI:10.7164/antibiotics.47.917

PMID:7928679

Abstract

Dnacin A1 and B1 were revealed to be new naphthyridinomycin-type antitumor antibiotics with formulae of C20H23N5O4 and C19H24N4O5, respectively. The gross structure of dnacin A1 was elucidated by the spectroscopic analyses. Conversion of dnacin B1 into A1 by treatment with potassium cyanide indicated the presence of an alpha-carbinolamine moiety in dnacin B1. The relative stereochemistry of dnacins was clarified by analysis of the NOESY spectra.

摘要

发现达纳辛A1和B1是新型萘啶霉素类抗肿瘤抗生素，其分子式分别为C20H23N5O4和C19H24N4O5。通过光谱分析阐明了达纳辛A1的总体结构。用氰化钾处理将达纳辛B1转化为A1，表明达纳辛B1中存在α-氨基醇部分。通过对NOESY谱的分析阐明了达纳辛的相对立体化学。