Coleman K, Athalye M, Clancey A, Davison M, Payne D J, Perry C R, Chopra I
SmithKline Beecham Pharmaceuticals, Microbiology Research, Betchworth, Surrey, UK.
J Antimicrob Chemother. 1994 Jun;33(6):1091-116. doi: 10.1093/jac/33.6.1091.
In the 50 years since antimicrobial agents were first introduced, bacteria have acquired a wide variety of mechanisms which have enabled them to resist the effects of these drugs. One way of overcoming this problem is to administer an antibiotic with an agent which counteracts the mechanism of resistance to that antibiotic; an example of such an approach which has already been successfully implemented is the combination of a beta-lactam antibiotic with a beta-lactamase inhibitor. This review describes antibiotic resistance mechanisms which might lend themselves to an inhibitor approach and the potential therapeutic applications of such a strategy.
自抗菌药物首次被引入以来的50年里，细菌已经获得了各种各样的机制，使它们能够抵抗这些药物的作用。克服这一问题的一种方法是将抗生素与一种能对抗该抗生素耐药机制的药物联合使用；一种已经成功实施的此类方法的例子是β-内酰胺抗生素与β-内酰胺酶抑制剂的联合使用。这篇综述描述了可能适用于抑制剂方法的抗生素耐药机制以及这种策略的潜在治疗应用。
