布托啡诺用于术后伤口疼痛患者的镇痛评估
Analgesic evaluation of butorphanol in patients with postoperative wound pain.
作者信息
Bauer R O, Bellville J W, Knox V, Capparell D
出版信息
Proc West Pharmacol Soc. 1976;19:266-72.
PMID:792893
Abstract
Two agonist/antagonist analgesics, butorphanol tartrate (test) and pentazocine hydrochloride (standard), were compared in volunteer informed patients experiencing postoperative wound pain. The relative potency (p) is 0.04 (1 mg butorphanol equals 24.3 mg of pentazocine lactate) with upper and lower confidence limits of 0.01 and 0.07 respectively. Butorphanol tartrate in the higher dose appears to have longer duration of effect. The side effects were comparable in the population studied.
摘要
在经历术后伤口疼痛的知情志愿者患者中，对两种激动剂/拮抗剂镇痛药酒石酸布托啡诺（试验药物）和盐酸喷他佐辛（标准药物）进行了比较。相对效价（p）为0.04（1毫克酒石酸布托啡诺相当于24.3毫克乳酸喷他佐辛），置信上限和下限分别为0.01和0.07。较高剂量的酒石酸布托啡诺似乎具有更长的作用持续时间。在所研究的人群中，副作用相当。
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