Holton J, Nye P, McDonald V
Department of Medical Microbiology, University College London Medical School, UK.
J Hosp Infect. 1994 Jun;27(2):105-15. doi: 10.1016/0195-6701(94)90003-5.
We have tested the in-vitro efficacy of various disinfectants against clinical isolates of Mycobacterium tuberculosis, Mycobacterium avium-intracellulare, and against the protozoon Cryptosporidium parvum. The disinfectants were tested both with and without an organic load. 'Sactimed sinald' (a quaternary ammonium compound), 'Steris 20' (a peracetic acid compound) and 'Pentapon DC1' (a beta-ene compound) were all equally as effective as 'Cidex' (glutaraldehyde) against all the mycobacteria tested, as well as C. parvum. 'Virkon' (a per-oxygen compound) and 'Phoraid' (an iodine compound) were less effective than glutaraldehyde. 'Pentapon DHY' (a beta-ene compound) was ineffective against any of the organisms tested. We have also assessed a method of determining disinfectant efficacy using [35S]-methionine labelling of proteins, which appears promising, although it requires further evaluation.
我们已经测试了多种消毒剂对结核分枝杆菌、鸟分枝杆菌胞内复合群临床分离株以及原生动物微小隐孢子虫的体外杀菌效果。消毒剂在有和没有有机负荷的情况下都进行了测试。“Sactimed sinald”（一种季铵化合物）、“Steris 20”（一种过氧乙酸化合物）和“Pentapon DC1”（一种β-烯化合物）对所有测试的分枝杆菌以及微小隐孢子虫的杀菌效果均与“Cidex”（戊二醛）相当。“Virkon”（一种过氧化合物）和“Phoraid”（一种碘化合物）的杀菌效果不如戊二醛。“Pentapon DHY”（一种β-烯化合物）对任何测试的生物体均无杀菌效果。我们还评估了一种使用[35S] - 蛋氨酸标记蛋白质来测定消毒剂效果的方法，该方法虽然需要进一步评估，但看起来很有前景。
