Freisleben H J, Lehr F, Fuchs J
Gustav-Embden-Zentrum der Biologischen Chemie, Johann Wolfgang Goethe-Universität, Frankfurt am Main, Federal Republic of Germany.
J Neural Transm Suppl. 1994;41:231-6. doi: 10.1007/978-3-7091-9324-2_29.
Immunosuppressed NMRI-mice (nu/nu) were raised and kept under germ-reduced conditions and fed with a germ-reduced diet (14 animals = controls). For another 14 mice 4 mg of selegiline were admixed to 10 kg of the diet. The 50% survival rate of the latter group was 160% from birth or 220% from the beginning of the study. The survival rate in weeks finally reached 350%, and the area under the curve 250%. The last mouse in the control group died at the age of 5 months, 2.5 months after the study was started; the last mouse in the selegiline group died at the age of 14.5 months, 1 year after the beginning of the study.
免疫抑制的NMRI小鼠（裸鼠）饲养在无菌条件下，喂食无菌饲料（14只动物作为对照）。另外14只小鼠的饲料中每10千克混入4毫克司来吉兰。后一组从出生起的50%生存率为160%，从研究开始起为220%。最终几周的生存率达到350%，曲线下面积为250%。对照组最后一只小鼠在研究开始2.5个月后的5个月龄时死亡；司来吉兰组最后一只小鼠在研究开始1年后的14.5个月龄时死亡。
