Ohta A, Baba S, Takizawa T, Adachi T
Bio Science Laboratories, Meiji Seika Kaisha, Ltd., Sakado, Japan.
J Nutr Sci Vitaminol (Tokyo). 1994 Apr;40(2):171-80. doi: 10.3177/jnsv.40.171.
Magnesium (Mg) is an essential dietary element that plays important roles, acting as a cofactor of many enzymes. Rats fed a Mg-deficient diet have been reported to exhibit auricular and facial peripheral hyperemia and hemorrhage. Moreover, increased intake of calcium (Ca) or phosphorus (P) has been reported to impair apparent absorption of Mg. We tried to induce such typical inflammation in Mg-deficient rats by feeding low-Mg, high-Ca, and high-P diets. Increasing concentrations of Ca or P in the experimental diets significantly decreased the apparent absorption of Mg. And all rats fed the low-Mg (0.25 mg/g diet), high-Ca (10.4 mg/g diet), and high-P (12.0 mg/g diet) diet exhibited auricular and facial peripheral-hyperemia and hemorrhage. Then, we used the low-Mg, high-Ca, and high-P diet to investigate the effects of the fructooligosaccharides (FO) on absorption of Mg and skin inflammation. In the rats fed FO-containing (1 or 5%) diet, apparent absorption of Mg was significantly increased as compared with that of the control (FO 0%) group. In the rats fed a 5% FO-containing diet and sufficient Mg (0.50 mg/g), auricular and facial peripheral hyperemia and hemorrhage were significantly reduced. We concluded that FO increased the Mg absorption in rats fed a low-Mg, high-Ca, and high-P diet. Moreover, FO reduced inflammation in Mg-deficient rats, such as peripheral hyperemia and hemorrhage.
镁（Mg）是一种必需的膳食元素，发挥着重要作用，充当许多酶的辅助因子。据报道，喂食缺镁饮食的大鼠会出现耳部和面部外周充血及出血。此外，据报道，钙（Ca）或磷（P）摄入量增加会损害镁的表观吸收率。我们试图通过喂食低镁、高钙和高磷饮食在缺镁大鼠中诱发这种典型炎症。实验饮食中钙或磷浓度的增加显著降低了镁的表观吸收率。所有喂食低镁（0.25毫克/克饮食）、高钙（10.4毫克/克饮食）和高磷（12.0毫克/克饮食）饮食的大鼠均出现耳部和面部外周充血及出血。然后，我们使用低镁、高钙和高磷饮食来研究低聚果糖（FO）对镁吸收和皮肤炎症的影响。在喂食含FO（1%或5%）饮食的大鼠中，与对照组（FO 0%）相比，镁的表观吸收率显著增加。在喂食含5% FO饮食和充足镁（0.50毫克/克）的大鼠中，耳部和面部外周充血及出血明显减少。我们得出结论，FO增加了喂食低镁、高钙和高磷饮食大鼠的镁吸收。此外，FO减轻了缺镁大鼠的炎症，如外周充血和出血。
