Research and Development, Abbott Nutrition, Adult Nutrition Research, Development & Scientific Affairs, Columbus, OH 43219, USA.
Evid Based Complement Alternat Med. 2011;2011:836267. doi: 10.1093/ecam/nen050. Epub 2011 Feb 20.
Dietary bioactive components that play a role in improving skeletal health have received considerable attention in complementary and alternative medicine practices as a result of their increased efficacy to combat chronic diseases. The objectives of this study were to evaluate the additive or synergistic effects of dried plum and fructooligosaccharides (FOS) and to determine whether dried plum and FOS or their combination in a soy protein-based diet can restore bone mass in ovarian hormone deficient rats. For this purpose, 72 3-month-old female Sprague-Dawley rats were divided into six groups (n = 12) and either ovariectomized (Ovx, five groups) or sham-operated (sham, one group). The rats were maintained on a semipurified standard diet for 45 days after surgery to establish bone loss. Thereafter, the rats were placed on one of the following dietary treatments for 60 days: casein-based diet (Sham and Ovx), soy-based diet (Ovx + soy) or soy-based diet with dried plum (Ovx + soy + plum), FOS (Ovx + soy + FOS) and combination of dried plum and FOS (Ovx + soy + plum + FOS). Soy protein in combination with the test compounds significantly improved whole-body bone mineral density (BMD). All test compounds in combination with soy protein significantly increased femoral BMD but the combination of soy protein, dried plum and FOS had the most pronounced effect in increasing lumbar BMD. Similarly, all of the test compounds increased ultimate load, indicating improved biomechanical properties. The positive effects of these test compounds on bone may be due to their ability to modulate bone resorption and formation, as shown by suppressed urinary deoxypyridinoline excretion and enhanced alkaline phosphatase activity.
由于其在治疗慢性疾病方面的更高功效，在补充和替代医学实践中，具有改善骨骼健康作用的膳食生物活性成分受到了相当大的关注。本研究的目的是评估干李和低聚果糖（FOS）的相加或协同作用，并确定干李和 FOS 或其在基于大豆蛋白的饮食中的组合是否可以恢复去卵巢激素缺乏大鼠的骨量。为此，将 72 只 3 月龄雌性 Sprague-Dawley 大鼠分为 6 组（n = 12），并进行卵巢切除术（Ovx，5 组）或假手术（sham，1 组）。手术后，大鼠在半纯化标准饮食中维持 45 天以建立骨丢失。此后，大鼠接受以下饮食治疗之一 60 天：基于酪蛋白的饮食（Sham 和 Ovx）、基于大豆的饮食（Ovx + soy）或基于大豆的饮食加干李（Ovx + soy + plum）、FOS（Ovx + soy + FOS）和干李与 FOS 的组合（Ovx + soy + plum + FOS）。大豆蛋白与测试化合物的组合显著提高了全身骨矿物质密度（BMD）。所有与大豆蛋白结合的测试化合物均显著增加了股骨 BMD，但大豆蛋白、干李和 FOS 的组合在增加腰椎 BMD 方面效果最为显著。同样，所有测试化合物均增加了最终负荷，表明生物力学性能得到改善。这些测试化合物对骨骼的积极影响可能归因于它们调节骨吸收和形成的能力，这表现为抑制尿脱氧吡啶啉排泄和增强碱性磷酸酶活性。
