Ripamonti U, Reddi A H
Medical Research Council/University of the Witwatersrand, Dental Research Institute, Johannesburg, South Africa.
J Periodontal Res. 1994 Jul;29(4):225-35. doi: 10.1111/j.1600-0765.1994.tb01216.x.
Initiation of osteogenesis and cementogenesis is a problem central to periodontal regeneration. A major advance in the understanding of bone formation has been the identification of an entirely new family of protein initiators, the bone morphogenetic proteins, that regulate cartilage and bone differentiation in vivo. The purification, genetic cloning and expression of recombinant human bone morphogenetic proteins (BMPs) have laid the foundation for the cellular and molecular dissection of bone development and regeneration. The striking evolutionary conservation of the BMP genes indicates that they are critical in the normal development and function of animals. In addition to postfetal osteogenesis, the BMPs may play multiple roles in embryonic development and organogenesis, including skeletogenesis and the development of craniofacial and dental tissues. The availability of recombinant human BMPs provides several challenges and opportunities to gain insights into the mechanisms regulating the regeneration of bone and cementum for optimal outcome in the periodontal patient.
成骨和牙骨质形成的启动是牙周再生的核心问题。对骨形成认识的一个重大进展是鉴定出了一个全新的蛋白质启动子家族，即骨形态发生蛋白，它们在体内调节软骨和骨的分化。重组人骨形态发生蛋白（BMPs）的纯化、基因克隆和表达为骨发育和再生的细胞及分子剖析奠定了基础。BMP基因显著的进化保守性表明它们对动物的正常发育和功能至关重要。除了出生后的成骨作用，BMPs可能在胚胎发育和器官形成中发挥多种作用，包括骨骼形成以及颅面和牙齿组织的发育。重组人BMPs的可得性为深入了解调节骨和牙骨质再生的机制以实现牙周病患者的最佳治疗效果带来了诸多挑战和机遇。
