Streckfus C F, Wu A J, Ship J A, Brown L J
EODFF/NIDR/NIH, Bethesda, MD 20892.
J Oral Pathol Med. 1994 Jul;23(6):280-3. doi: 10.1111/j.1600-0714.1994.tb00060.x.
Stimulated parotid salivary flow rates were compared in elderly normotensive, hypertensive, and controlled hypertensive African-Americans, the latter group taking hydrochlorothiazide (HCTZ). The normotensive group consisted of 15 healthy unmedicated subjects with systolic blood pressures of less than 150 mm Hg and diastolic pressures less than 90 mm Hg. The hypertensive group consisted of 10 unmedicated subjects with systolic pressures greater than 160 mm Hg and diastolic pressures greater than 100 mm Hg. The controlled hypertensive group consisted of 20 subjects taking HCTZ (50 mg, daily) with controlled blood pressures similar to the normotensive control group. Stimulated parotid salivary samples were collected from each subject. A 2% citrate solution applied to the dorsum of the tongue was used for stimulation. The results showed no significant differences in stimulated parotid flow rates between normotensive and uncontrolled hypertensive subjects. However, the medicated, controlled hypertensive subjects had a significant reduction of stimulated parotid salivary flow rates compared to both the normotensive and hypertensive groups.
对老年血压正常、高血压和血压得到控制的非裔美国高血压患者的腮腺唾液刺激流速进行了比较，后一组服用氢氯噻嗪（HCTZ）。血压正常组由15名未服用药物的健康受试者组成，收缩压低于150毫米汞柱，舒张压低于90毫米汞柱。高血压组由10名未服用药物的受试者组成，收缩压高于160毫米汞柱，舒张压高于100毫米汞柱。血压得到控制的高血压组由20名服用HCTZ（每日50毫克）的受试者组成，其血压得到控制，与血压正常的对照组相似。从每个受试者收集腮腺唾液刺激样本。用涂抹于舌背的2%柠檬酸盐溶液进行刺激。结果显示，血压正常和未得到控制的高血压受试者之间的腮腺刺激流速没有显著差异。然而，与血压正常组和高血压组相比，服用药物且血压得到控制的高血压受试者的腮腺唾液刺激流速显著降低。
