Bauer M S, Kurtz J W, Rubin L B, Marcus J G
Department of Veterans Affairs Medical Center, Brown University Department of Psychiatry and Human Behavior, Providence, Rhode Island.
J Psychiatr Res. 1994 Mar-Apr;28(2):135-45. doi: 10.1016/0022-3956(94)90025-6.
This study investigated (1) the time-course and durability of antidepressant effects of bright light in winter depressives, and (2) the effects of bright light on mood and behavior in normal controls in a 4-week open treatment paradigm. Twelve subjects in a major depressive episode during recurrent major depressive or bipolar disorder with seasonal pattern and 12 control subjects received 2,500 lux light between 0600 and 0800 hours, while 12 controls arose at 0600 hours for quiet activities without exposure to bright light. In depressives, maximal decrements in depression ratings were not reached until the fourth week of treatment. Four depressives experienced clinically significant hypomanic symptoms. Controls treated with light demonstrated significantly higher clinician ratings of hypomanic symptoms than no-light controls. When depressives and controls were combined, seasonality, but not diagnosis, predicted the emergence of manic-like symptoms. Implications for bright light treatment in the clinical setting are discussed.
（1）冬季抑郁症患者中明亮光线抗抑郁作用的时间进程和持久性；（2）在为期4周的开放治疗模式下，明亮光线对正常对照者情绪和行为的影响。12名患有复发性重度抑郁或双相情感障碍且有季节性模式的重度抑郁发作患者以及12名对照者在06:00至08:00期间接受2500勒克斯光照，而另外12名对照者于06:00起床进行安静活动，不暴露于明亮光线下。在抑郁症患者中，直到治疗第四周才达到抑郁评分的最大降幅。4名抑郁症患者出现了具有临床意义的轻躁狂症状。接受光照治疗的对照者的轻躁狂症状临床评分显著高于未接受光照的对照者。当将抑郁症患者和对照者合并分析时，季节性而非诊断能预测出类似躁狂症状的出现。文中讨论了在临床环境中进行明亮光线治疗的意义。
