Bauer M S, Kurtz J, Winokur A, Phillips J, Rubin L B, Marcus J G
Department of Veterans Affairs Medical Center, Providence, RI 02908-4799.
Psychoneuroendocrinology. 1993;18(5-6):437-43. doi: 10.1016/0306-4530(93)90018-g.
Thyroid function in patients in a current major depressive episode during the course of recurrent major mood disorder with seasonal pattern according to DSM-IIIR was compared to that of controls before and after 4 weeks' light treatment, and to that of controls at baseline and after 4 weeks' of arising early without exposure to bright light. No consistent abnormalities in thyroxine, free thyroxine index, triiodothyronine, reverse triiodothyronine, thyrotropin, thyrotropin response to TRH infusion, or thyroid autoantibodies were seen in depressives at baseline. No differences in these parameters were seen at baseline between depressives and controls. No intergroup differences were seen with treatment, although reverse T3 decreased significantly during the protocol in all groups. These data do not support the hypothesis that the thyroid axis plays a role in the pathogenesis of winter depressive symptoms or their response to light treatment.
根据《精神疾病诊断与统计手册第三版修订本》（DSM-IIIR），对季节性复发性重性心境障碍当前处于重性抑郁发作期患者的甲状腺功能，在接受4周光照治疗前后，与基线时及早起4周且未暴露于强光下的对照组进行比较。在基线时，抑郁症患者在甲状腺素、游离甲状腺素指数、三碘甲状腺原氨酸、反三碘甲状腺原氨酸、促甲状腺激素、促甲状腺激素对促甲状腺激素释放激素输注的反应或甲状腺自身抗体方面，均未发现一致的异常。抑郁症患者与对照组在基线时这些参数无差异。治疗后组间未观察到差异，尽管在方案实施过程中所有组的反三碘甲状腺原氨酸均显著下降。这些数据不支持甲状腺轴在冬季抑郁症状的发病机制或其对光照治疗的反应中起作用这一假说。
