Anderson W I, Inhelder J L, King N W
Department of Pathology, Wyeth-Ayerst Research, Chazy, NY 12921.
J Med Primatol. 1994 Jan;23(1):56-7. doi: 10.1111/j.1600-0684.1994.tb00097.x.
Spontaneous lymphosarcoma, likely of renal origin, was diagnosed in a naive, juvenile, male cynomolgus monkey (Macaca fascicularis). Histologically, renal architecture was effaced by dense infiltrating sheets of plump cells with indistinct borders and scant amphophilic cytoplasm. Mitoses were uncommon. Similar neoplastic infiltrates were also present in the right renal cortex, one adrenal medulla, the prostate, seminal vesicles, myocardium, and the pulmonary interstitium. Serological tests were negative for infection with Simian Immunodeficiency Virus (SIV), Simian T-Lymphotropic Virus-1 (STLV-1), and Simian Retrovirus-5.
在一只未经免疫的幼年雄性食蟹猴（猕猴属）中诊断出可能起源于肾脏的自发性淋巴肉瘤。组织学检查显示，肾脏结构被大量浸润的丰满细胞片层所取代，这些细胞边界不清，胞质嗜双色性且稀少。有丝分裂少见。右肾皮质、一个肾上腺髓质、前列腺、精囊、心肌和肺间质中也存在类似的肿瘤浸润。血清学检测显示，该猴感染猴免疫缺陷病毒（SIV）、猴T淋巴细胞白血病病毒1型（STLV-1）和猴逆转录病毒5型均为阴性。
