Suda K, Komatsu K, Hashimoto K
Acta Pathol Jpn. 1976 Sep;26(5):561-72. doi: 10.1111/j.1440-1827.1976.tb00513.x.
In autopsy material isolated islets of Langerhans are frequently encountered in the fatty or the fibrous tissue replacing the pancreatic lobuli. The incidence of isolated islets of Langerhans was 27.0% in the file of a series of randomly selected 100 autopsy cases and increased with advancing age. Fifteen cases of these 27 showed multiple foci and the total number of foci counted 60. Fifty-two foci (86.7%) were found in the subcapsular area. Clusters of elastic fibers were found in 36 foci (60.0%). Small pancreatic ducts with goblet cell metaplasia were found in 29 foci (48.0%) in the surrounding tissue of the remaining islets of Langerhans. Squamous metaplasia was identified in only 1 focus (0.2%), and luminal dilatation of the duct was found in 4 foci (0.7%). Serial sections showed that the small duct ended without connection to acinar cells. "The isolated islets of Langerhans" should be the result of the atrophy of pancreatic lobuli subsequent to disappearance of acinar cells.
在尸检材料中，常可在取代胰腺小叶的脂肪组织或纤维组织中发现孤立的胰岛。在一系列随机选取的100例尸检病例档案中，孤立胰岛的发生率为27.0%，且随年龄增长而增加。这27例中有15例出现多个病灶，病灶总数为60个。52个病灶（86.7%）位于被膜下区域。在36个病灶（60.0%）中发现了弹性纤维束。在其余胰岛周围组织的29个病灶（48.0%）中发现了伴有杯状细胞化生的小胰管。仅在1个病灶（0.2%）中发现了鳞状化生，在4个病灶（0.7%）中发现了导管管腔扩张。连续切片显示小导管末端未与腺泡细胞相连。“孤立的胰岛”应是腺泡细胞消失后胰腺小叶萎缩的结果。
