Szczeklik A, Nizankowska E, Nizankowski R
Respiration. 1977;34(6):323-31. doi: 10.1159/000193844.
Bronchial reactivity to prostaglandins F2alpha (PGF2alpha), E2 (PGE2) and histamine has been studied in 27 patients with aspirin-sensitive asthma and in 28 asthmatics without this sensitivity. Of the latter group, 13 patients had atopic, 9 infectious, and 6 mixed type of asthma. Atopic patients were characterized by vivid reactivity to low doses of both PGF2alpha and histamine. In patients with infectious asthma significantly higher doses of both PGF2alpha and histamine were necessary to induce bronchoconstriction as compared to atopics. Aspirin-sensitive patients responded quickly with bronchial spasm to similar doses of histamine as atopics, but tolerated significantly higher doses of PGF2alpha. There was no difference in reactivity to PGF2alpha between patients with aspirin sensitivity and those with infectious asthma. 5 and 10 min after administration of 60 microgram PGE2 significantly better improvement in ventilation occurred in aspirin-sensitive patients than in those of either atopic or infectious groups. The results obtained point to differences in bronchial reactivity to prostaglandins and histamine depending on type of asthma and severity of its symptoms.
对27例阿司匹林敏感性哮喘患者和28例无此敏感性的哮喘患者研究了支气管对前列腺素F2α（PGF2α）、E2（PGE2）和组胺的反应性。在后一组中，13例患者为特应性哮喘，9例为感染性哮喘，6例为混合型哮喘。特应性患者的特点是对低剂量的PGF2α和组胺均有明显反应。与特应性哮喘患者相比，感染性哮喘患者需要显著更高剂量的PGF2α和组胺才能诱发支气管收缩。阿司匹林敏感性患者对与特应性哮喘患者相似剂量的组胺会迅速出现支气管痉挛反应，但能耐受显著更高剂量的PGF2α。阿司匹林敏感性患者与感染性哮喘患者对PGF2α的反应性无差异。给予60微克PGE2后5分钟和10分钟，阿司匹林敏感性患者的通气改善明显优于特应性或感染性哮喘组患者。所得结果表明，支气管对前列腺素和组胺的反应性因哮喘类型及其症状严重程度而异。
